Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2885725..2886434 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FF952_RS13530 Protein ID WP_003413164.1
Coordinates 2885725..2886138 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FF952_RS13535 Protein ID WP_003413167.1
Coordinates 2886177..2886434 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS13500 (FF952_13970) 2880778..2881983 - 1206 WP_003413027.1 chorismate synthase -
FF952_RS13505 (FF952_13975) 2882091..2882405 + 315 WP_009937839.1 hypothetical protein -
FF952_RS13510 (FF952_13980) 2882701..2883912 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FF952_RS13515 (FF952_13990) 2884039..2884698 + 660 WP_003900846.1 LppA family lipoprotein -
FF952_RS13520 (FF952_13995) 2884695..2885357 + 663 WP_031698290.1 LppA family lipoprotein -
FF952_RS13525 (FF952_14000) 2885354..2885632 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FF952_RS13530 (FF952_14005) 2885725..2886138 + 414 WP_003413164.1 PIN domain nuclease Toxin
FF952_RS13535 (FF952_14010) 2886177..2886434 + 258 WP_003413167.1 CopG family transcriptional regulator Antitoxin
FF952_RS13540 (FF952_14015) 2886431..2886808 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FF952_RS13545 (FF952_14020) 2886824..2887198 - 375 WP_003413177.1 hypothetical protein -
FF952_RS13550 (FF952_14025) 2887298..2887693 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FF952_RS13555 (FF952_14030) 2887690..2887935 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FF952_RS13560 (FF952_14040) 2888346..2888765 - 420 WP_003413190.1 A24 family peptidase -
FF952_RS13565 (FF952_14045) 2888777..2889586 - 810 WP_003413193.1 shikimate dehydrogenase -
FF952_RS13570 (FF952_14050) 2889583..2890836 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FF952_RS13575 (FF952_14055) 2890829..2891341 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-122)

Antitoxin

(2-38)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T126602 WP_003413164.1 NZ_CP040689:2885725-2886138 [Mycobacterium tuberculosis complex sp. N0072]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T126602 NZ_CP040689:2885725-2886138 [Mycobacterium tuberculosis complex sp. N0072]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT126602 WP_003413167.1 NZ_CP040689:2886177-2886434 [Mycobacterium tuberculosis complex sp. N0072]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT126602 NZ_CP040689:2886177-2886434 [Mycobacterium tuberculosis complex sp. N0072]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ26


Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References