Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2825653..2826305 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag FF952_RS13250 Protein ID WP_003412752.1
Coordinates 2825880..2826305 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag FF952_RS13245 Protein ID WP_003412749.1
Coordinates 2825653..2825874 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS13230 (FF952_13670) 2823893..2824099 - 207 WP_003899347.1 hypothetical protein -
FF952_RS13235 (FF952_13675) 2824235..2824858 + 624 WP_003900858.1 TIGR00725 family protein -
FF952_RS13240 (FF952_13680) 2824848..2825600 + 753 WP_003901416.1 hypothetical protein -
FF952_RS13245 (FF952_13685) 2825653..2825874 + 222 WP_003412749.1 antitoxin Antitoxin
FF952_RS13250 (FF952_13690) 2825880..2826305 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
FF952_RS13255 (FF952_13695) 2826328..2827509 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
FF952_RS13260 (FF952_13700) 2827506..2828552 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
FF952_RS13265 (FF952_13705) 2828563..2829666 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
FF952_RS13270 (FF952_13710) 2829925..2830746 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
FF952_RS13275 (FF952_13715) 2830743..2831300 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T126600 WP_003412752.1 NZ_CP040689:2825880-2826305 [Mycobacterium tuberculosis complex sp. N0072]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T126600 NZ_CP040689:2825880-2826305 [Mycobacterium tuberculosis complex sp. N0072]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT126600 WP_003412749.1 NZ_CP040689:2825653-2825874 [Mycobacterium tuberculosis complex sp. N0072]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT126600 NZ_CP040689:2825653-2825874 [Mycobacterium tuberculosis complex sp. N0072]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References