Detailed information of TA system TA126599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2423029..2423558
• Replicon: chromosome
• Accession: NZ_CP040689
• Organism: Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: FF952_RS11350
• Protein ID: WP_003411124.1
• Coordinates: 2423029..2423346 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: FF952_RS11355
• Protein ID: WP_003411127.1
• Coordinates: 2423343..2423558 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF952_RS11320 (FF952_11700)	2418224..2419300	+	1077	WP_003904789.1	hypothetical protein	-
FF952_RS11325 (FF952_11705)	2419297..2419578	+	282	WP_003411112.1	DUF5703 family protein	-
FF952_RS11330 (FF952_11710)	2419614..2420687	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
FF952_RS11335 (FF952_11715)	2420692..2421222	-	531	WP_003904790.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
FF952_RS11340 (FF952_11720)	2421270..2422616	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
FF952_RS11350 (FF952_11730)	2423029..2423346	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FF952_RS11355 (FF952_11735)	2423343..2423558	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
FF952_RS11360 (FF952_11740)	2423813..2424871	+	1059	WP_003904791.1	phosphoribosyltransferase family protein	-
FF952_RS11365 (FF952_11745)	2425001..2425357	-	357	WP_003411130.1	hypothetical protein	-
FF952_RS11370 (FF952_11750)	2425452..2426234	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
FF952_RS11375 (FF952_11755)	2426502..2426792	-	291	WP_003900476.1	YggT family protein	-
FF952_RS11380 (FF952_11760)	2426954..2427610	-	657	WP_003411133.1	cell division protein SepF	-
FF952_RS11385 (FF952_11765)	2427676..2428452	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T126599 WP_003411124.1 NZ_CP040689:c2423346-2423029 [Mycobacterium tuberculosis complex sp. N0072]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T126599 NZ_CP040689:c2423346-2423029 [Mycobacterium tuberculosis complex sp. N0072]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT126599 WP_003411127.1 NZ_CP040689:c2423558-2423343 [Mycobacterium tuberculosis complex sp. N0072]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT126599 NZ_CP040689:c2423558-2423343 [Mycobacterium tuberculosis complex sp. N0072]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4