Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 2386340..2387035 | Replicon | chromosome |
Accession | NZ_CP040689 | ||
Organism | Mycobacterium tuberculosis complex sp. N0072 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | O53501 |
Locus tag | FF952_RS11145 | Protein ID | WP_003410811.1 |
Coordinates | 2386340..2386774 (-) | Length | 145 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TMN0 |
Locus tag | FF952_RS11150 | Protein ID | WP_003410814.1 |
Coordinates | 2386781..2387035 (-) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FF952_RS11135 (FF952_11515) | 2382494..2385535 | + | 3042 | WP_003899171.1 | DEAD/DEAH box helicase | - |
FF952_RS11140 (FF952_11520) | 2385528..2386361 | + | 834 | WP_003899172.1 | SWIM zinc finger family protein | - |
FF952_RS11145 (FF952_11525) | 2386340..2386774 | - | 435 | WP_003410811.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FF952_RS11150 (FF952_11530) | 2386781..2387035 | - | 255 | WP_003410814.1 | antitoxin | Antitoxin |
FF952_RS11155 (FF952_11535) | 2387051..2387308 | - | 258 | WP_003410816.1 | hypothetical protein | - |
FF952_RS11160 (FF952_11545) | 2388254..2388550 | + | 297 | WP_003410820.1 | PE family protein | - |
FF952_RS11165 (FF952_11550) | 2388606..2389337 | + | 732 | Protein_2208 | PPE family protein | - |
FF952_RS11170 (FF952_11555) | 2389877..2390623 | - | 747 | WP_003901330.1 | proteasome subunit alpha | - |
FF952_RS11175 (FF952_11560) | 2390620..2391495 | - | 876 | WP_003411023.1 | proteasome subunit beta | - |
FF952_RS11180 (FF952_11565) | 2391492..2391686 | - | 195 | WP_003411026.1 | ubiquitin-like protein Pup | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 145 a.a. Molecular weight: 15662.08 Da Isoelectric Point: 7.4681
>T126598 WP_003410811.1 NZ_CP040689:c2386774-2386340 [Mycobacterium tuberculosis complex sp. N0072]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL
Download Length: 435 bp
>T126598 NZ_CP040689:c2386774-2386340 [Mycobacterium tuberculosis complex sp. N0072]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9417.57 Da Isoelectric Point: 8.9912
>AT126598 WP_003410814.1 NZ_CP040689:c2387035-2386781 [Mycobacterium tuberculosis complex sp. N0072]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS
Download Length: 255 bp
>AT126598 NZ_CP040689:c2387035-2386781 [Mycobacterium tuberculosis complex sp. N0072]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FB09 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TMN0 |