Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2386340..2387035 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag FF952_RS11145 Protein ID WP_003410811.1
Coordinates 2386340..2386774 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag FF952_RS11150 Protein ID WP_003410814.1
Coordinates 2386781..2387035 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS11135 (FF952_11515) 2382494..2385535 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
FF952_RS11140 (FF952_11520) 2385528..2386361 + 834 WP_003899172.1 SWIM zinc finger family protein -
FF952_RS11145 (FF952_11525) 2386340..2386774 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
FF952_RS11150 (FF952_11530) 2386781..2387035 - 255 WP_003410814.1 antitoxin Antitoxin
FF952_RS11155 (FF952_11535) 2387051..2387308 - 258 WP_003410816.1 hypothetical protein -
FF952_RS11160 (FF952_11545) 2388254..2388550 + 297 WP_003410820.1 PE family protein -
FF952_RS11165 (FF952_11550) 2388606..2389337 + 732 Protein_2208 PPE family protein -
FF952_RS11170 (FF952_11555) 2389877..2390623 - 747 WP_003901330.1 proteasome subunit alpha -
FF952_RS11175 (FF952_11560) 2390620..2391495 - 876 WP_003411023.1 proteasome subunit beta -
FF952_RS11180 (FF952_11565) 2391492..2391686 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T126598 WP_003410811.1 NZ_CP040689:c2386774-2386340 [Mycobacterium tuberculosis complex sp. N0072]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T126598 NZ_CP040689:c2386774-2386340 [Mycobacterium tuberculosis complex sp. N0072]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT126598 WP_003410814.1 NZ_CP040689:c2387035-2386781 [Mycobacterium tuberculosis complex sp. N0072]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT126598 NZ_CP040689:c2387035-2386781 [Mycobacterium tuberculosis complex sp. N0072]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References