Detailed information of TA system TA126595

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2275284..2275910
• Replicon: chromosome
• Accession: NZ_CP040689
• Organism: Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P64926
• Locus tag: FF952_RS10660
• Protein ID: WP_003410075.1
• Coordinates: 2275512..2275910 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A806JLL8
• Locus tag: FF952_RS10655
• Protein ID: WP_003911750.1
• Coordinates: 2275284..2275511 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF952_RS10645 (FF952_11010)	2273323..2273667	-	345	WP_003410065.1	ferredoxin family protein	-
FF952_RS10650 (FF952_11015)	2273856..2275025	-	1170	WP_003899126.1	ATP-binding protein	-
FF952_RS10655 (FF952_11020)	2275284..2275511	+	228	WP_003911750.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FF952_RS10660 (FF952_11025)	2275512..2275910	+	399	WP_003410075.1	PIN domain nuclease	Toxin
FF952_RS10665 (FF952_11030)	2276093..2276524	-	432	WP_003410078.1	MarR family winged helix-turn-helix transcriptional regulator	-
FF952_RS10670 (FF952_11035)	2276625..2277059	+	435	WP_003914358.1	DUF1398 domain-containing protein	-
FF952_RS10675 (FF952_11050)	2277496..2277675	-	180	Protein_2110	hypothetical protein	-
FF952_RS10680 (FF952_11055)	2277763..2278383	+	621	WP_003410086.1	IS110 family transposase	-
FF952_RS10685 (FF952_11060)	2278337..2278927	+	591	WP_003899131.1	IS110 family transposase	-
FF952_RS10690 (FF952_11065)	2279055..2280311	-	1257	WP_003902247.1	HNH endonuclease signature motif containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-120)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-43)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14731.02 Da
• Isoelectric Point: 6.7067

>T126595 WP_003410075.1 NZ_CP040689:2275512-2275910 [Mycobacterium tuberculosis complex sp. N0072]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Nucleotide

• Length: 399 bp

>T126595 NZ_CP040689:2275512-2275910 [Mycobacterium tuberculosis complex sp. N0072]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8346.16 Da
• Isoelectric Point: 4.1621

>AT126595 WP_003911750.1 NZ_CP040689:2275284-2275511 [Mycobacterium tuberculosis complex sp. N0072]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Nucleotide

• Length: 228 bp

>AT126595 NZ_CP040689:2275284-2275511 [Mycobacterium tuberculosis complex sp. N0072]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Structures

Toxin

• PDB: 4CHG

Antitoxin

• AlphaFold DB: A0A806JLL8