Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2249978..2250876 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FF952_RS10535 Protein ID WP_003410001.1
Coordinates 2249978..2250538 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FF952_RS10540 Protein ID WP_003410003.1
Coordinates 2250535..2250876 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS10505 (FF952_10870) 2245147..2245800 - 654 WP_003409976.1 cutinase Cfp21 -
FF952_RS10510 (FF952_10875) 2245915..2246145 + 231 WP_003409980.1 DUF167 domain-containing protein -
FF952_RS10515 (FF952_10880) 2246230..2247141 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FF952_RS10520 (FF952_10885) 2247250..2247849 + 600 WP_003409989.1 L-lysine exporter -
FF952_RS10525 (FF952_10890) 2248265..2248693 + 429 WP_003409992.1 cellulose-binding protein -
FF952_RS10530 (FF952_10895) 2248919..2249458 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FF952_RS10535 (FF952_10905) 2249978..2250538 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
FF952_RS10540 (FF952_10910) 2250535..2250876 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
FF952_RS10545 (FF952_10915) 2250962..2251219 + 258 WP_003410006.1 hypothetical protein -
FF952_RS10550 (FF952_10920) 2251120..2251455 - 336 WP_003410009.1 dehydrogenase -
FF952_RS10555 (FF952_10925) 2251544..2251888 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
FF952_RS10560 (FF952_10930) 2251882..2252130 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
FF952_RS10565 (FF952_10935) 2252230..2254545 - 2316 WP_003899120.1 cation transporter ATPase CptG -
FF952_RS10570 (FF952_10940) 2254542..2254814 - 273 WP_003903706.1 DUF1490 family protein -
FF952_RS10575 (FF952_10945) 2254867..2255223 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T126593 WP_003410001.1 NZ_CP040689:c2250538-2249978 [Mycobacterium tuberculosis complex sp. N0072]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T126593 NZ_CP040689:c2250538-2249978 [Mycobacterium tuberculosis complex sp. N0072]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT126593 WP_003410003.1 NZ_CP040689:c2250876-2250535 [Mycobacterium tuberculosis complex sp. N0072]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT126593 NZ_CP040689:c2250876-2250535 [Mycobacterium tuberculosis complex sp. N0072]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References