Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2242652..2243340 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag FF952_RS10490 Protein ID WP_003409958.1
Coordinates 2242652..2243071 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag FF952_RS10495 Protein ID WP_003409968.1
Coordinates 2243080..2243340 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS10470 (FF952_10835) 2238147..2238995 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
FF952_RS10475 (FF952_10840) 2238958..2240403 - 1446 WP_003409946.1 APC family permease -
FF952_RS10480 (FF952_10845) 2240582..2241268 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
FF952_RS10485 (FF952_10850) 2241459..2242427 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
FF952_RS10490 (FF952_10855) 2242652..2243071 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
FF952_RS10495 (FF952_10860) 2243080..2243340 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FF952_RS10500 (FF952_10865) 2243483..2245159 + 1677 WP_003904753.1 PecA family PE domain-processing aspartic protease -
FF952_RS10505 (FF952_10870) 2245147..2245800 - 654 WP_003409976.1 cutinase Cfp21 -
FF952_RS10510 (FF952_10875) 2245915..2246145 + 231 WP_003409980.1 DUF167 domain-containing protein -
FF952_RS10515 (FF952_10880) 2246230..2247141 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FF952_RS10520 (FF952_10885) 2247250..2247849 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T126592 WP_003409958.1 NZ_CP040689:c2243071-2242652 [Mycobacterium tuberculosis complex sp. N0072]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T126592 NZ_CP040689:c2243071-2242652 [Mycobacterium tuberculosis complex sp. N0072]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT126592 WP_003409968.1 NZ_CP040689:c2243340-2243080 [Mycobacterium tuberculosis complex sp. N0072]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT126592 NZ_CP040689:c2243340-2243080 [Mycobacterium tuberculosis complex sp. N0072]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References