Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2216424..2216968 | Replicon | chromosome |
| Accession | NZ_CP040689 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0072 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FF952_RS10340 | Protein ID | WP_003409896.1 |
| Coordinates | 2216424..2216720 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FF952_RS10345 | Protein ID | WP_003409899.1 |
| Coordinates | 2216717..2216968 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF952_RS10285 (FF952_10630) | 2211457..2211807 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| FF952_RS10290 (FF952_10635) | 2211818..2212720 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| FF952_RS10295 (FF952_10640) | 2212741..2212932 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FF952_RS10300 (FF952_10645) | 2212933..2213229 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FF952_RS10305 (FF952_10650) | 2213469..2213684 | + | 216 | WP_003409878.1 | antitoxin | - |
| FF952_RS10310 (FF952_10655) | 2213681..2213992 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF952_RS10315 | 2213966..2214487 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FF952_RS10320 (FF952_10665) | 2214462..2214839 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FF952_RS10325 (FF952_10670) | 2214881..2215330 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FF952_RS10330 (FF952_10675) | 2215327..2215872 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FF952_RS10335 (FF952_10680) | 2215761..2216375 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FF952_RS10340 (FF952_10685) | 2216424..2216720 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FF952_RS10345 (FF952_10690) | 2216717..2216968 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FF952_RS10350 (FF952_10695) | 2216955..2217449 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FF952_RS10355 (FF952_10700) | 2217609..2218016 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF952_RS10360 (FF952_10705) | 2218020..2218292 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FF952_RS10365 (FF952_10710) | 2218325..2219545 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FF952_RS10370 (FF952_10725) | 2220444..2221241 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T126591 WP_003409896.1 NZ_CP040689:c2216720-2216424 [Mycobacterium tuberculosis complex sp. N0072]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T126591 NZ_CP040689:c2216720-2216424 [Mycobacterium tuberculosis complex sp. N0072]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT126591 WP_003409899.1 NZ_CP040689:c2216968-2216717 [Mycobacterium tuberculosis complex sp. N0072]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT126591 NZ_CP040689:c2216968-2216717 [Mycobacterium tuberculosis complex sp. N0072]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |