Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1973959..1974419 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag FF952_RS09235 Protein ID WP_003898996.1
Coordinates 1974171..1974419 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JZ84
Locus tag FF952_RS09230 Protein ID WP_003904688.1
Coordinates 1973959..1974171 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T126588 WP_003898996.1 NZ_CP040689:1974171-1974419 [Mycobacterium tuberculosis complex sp. N0072]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T126588 NZ_CP040689:1974171-1974419 [Mycobacterium tuberculosis complex sp. N0072]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7577.77 Da        Isoelectric Point: 9.3146

>AT126588 WP_003904688.1 NZ_CP040689:1973959-1974171 [Mycobacterium tuberculosis complex sp. N0072]
MELAARMGETLTQAVVVAVREQLARRAGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT126588 NZ_CP040689:1973959-1974171 [Mycobacterium tuberculosis complex sp. N0072]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGGC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A806JZ84

References