Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1973959..1974419 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag FF952_RS09235 Protein ID WP_003898996.1
Coordinates 1974171..1974419 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JZ84
Locus tag FF952_RS09230 Protein ID WP_003904688.1
Coordinates 1973959..1974171 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS09215 (FF952_09505) 1970437..1971624 - 1188 WP_003898992.1 nitrate transporter NarK -
FF952_RS09220 (FF952_09510) 1971911..1972195 + 285 WP_003408522.1 DUF1876 domain-containing protein -
FF952_RS09225 (FF952_09515) 1972209..1973891 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
FF952_RS09230 (FF952_09520) 1973959..1974171 + 213 WP_003904688.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FF952_RS09235 (FF952_09525) 1974171..1974419 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
FF952_RS09240 (FF952_09530) 1974427..1975164 + 738 WP_003898997.1 hypothetical protein -
FF952_RS09245 (FF952_09535) 1975258..1976958 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
FF952_RS09250 (FF952_09540) 1977243..1977644 - 402 WP_003408538.1 hypothetical protein -
FF952_RS09255 (FF952_09545) 1977634..1978245 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T126588 WP_003898996.1 NZ_CP040689:1974171-1974419 [Mycobacterium tuberculosis complex sp. N0072]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T126588 NZ_CP040689:1974171-1974419 [Mycobacterium tuberculosis complex sp. N0072]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7577.77 Da        Isoelectric Point: 9.3146

>AT126588 WP_003904688.1 NZ_CP040689:1973959-1974171 [Mycobacterium tuberculosis complex sp. N0072]
MELAARMGETLTQAVVVAVREQLARRAGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT126588 NZ_CP040689:1973959-1974171 [Mycobacterium tuberculosis complex sp. N0072]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGGC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A806JZ84

References