Detailed information of TA system TA126587

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1953056..1953669
• Replicon: chromosome
• Accession: NZ_CP040689
• Organism: Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WFA2
• Locus tag: FF952_RS09120
• Protein ID: WP_003408465.1
• Coordinates: 1953056..1953445 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ52
• Locus tag: FF952_RS09125
• Protein ID: WP_003408469.1
• Coordinates: 1953442..1953669 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF952_RS09085 (FF952_09375)	1948685..1949599	+	915	WP_003898985.1	3-hydroxyacyl-CoA dehydrogenase family protein	-
FF952_RS09090 (FF952_09380)	1949602..1950432	+	831	WP_003408448.1	cyclase family protein	-
FF952_RS09095 (FF952_09385)	1950432..1950782	+	351	WP_003898986.1	cupin domain-containing protein	-
FF952_RS09100 (FF952_09390)	1950835..1951653	+	819	WP_003408456.1	3-keto-5-aminohexanoate cleavage protein	-
FF952_RS09105 (FF952_09395)	1951667..1952446	+	780	WP_003408460.1	IclR family transcriptional regulator	-
FF952_RS09115	1952877..1953008	+	132	Protein_1798	IS3 family transposase	-
FF952_RS09120 (FF952_09405)	1953056..1953445	-	390	WP_003408465.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF952_RS09125 (FF952_09410)	1953442..1953669	-	228	WP_003408469.1	antitoxin	Antitoxin
FF952_RS09130 (FF952_09415)	1953887..1955371	+	1485	WP_003904684.1	biotin carboxylase	-
FF952_RS09135 (FF952_09420)	1955368..1956615	+	1248	WP_003408476.1	serine hydrolase	-
FF952_RS09140 (FF952_09425)	1956658..1957077	-	420	WP_003904685.1	hypothetical protein	-
FF952_RS09145 (FF952_09430)	1957067..1957777	-	711	WP_003408486.1	winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-116)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 13817.98 Da
• Isoelectric Point: 7.0612

>T126587 WP_003408465.1 NZ_CP040689:c1953445-1953056 [Mycobacterium tuberculosis complex sp. N0072]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Nucleotide

• Length: 390 bp

>T126587 NZ_CP040689:c1953445-1953056 [Mycobacterium tuberculosis complex sp. N0072]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8226.39 Da
• Isoelectric Point: 4.3313

>AT126587 WP_003408469.1 NZ_CP040689:c1953669-1953442 [Mycobacterium tuberculosis complex sp. N0072]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Nucleotide

• Length: 228 bp

>AT126587 NZ_CP040689:c1953669-1953442 [Mycobacterium tuberculosis complex sp. N0072]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BUI9

Antitoxin

• AlphaFold DB: A0A7U4FAN9