Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1953056..1953669 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag FF952_RS09120 Protein ID WP_003408465.1
Coordinates 1953056..1953445 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FF952_RS09125 Protein ID WP_003408469.1
Coordinates 1953442..1953669 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS09085 (FF952_09375) 1948685..1949599 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
FF952_RS09090 (FF952_09380) 1949602..1950432 + 831 WP_003408448.1 cyclase family protein -
FF952_RS09095 (FF952_09385) 1950432..1950782 + 351 WP_003898986.1 cupin domain-containing protein -
FF952_RS09100 (FF952_09390) 1950835..1951653 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
FF952_RS09105 (FF952_09395) 1951667..1952446 + 780 WP_003408460.1 IclR family transcriptional regulator -
FF952_RS09115 1952877..1953008 + 132 Protein_1798 IS3 family transposase -
FF952_RS09120 (FF952_09405) 1953056..1953445 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
FF952_RS09125 (FF952_09410) 1953442..1953669 - 228 WP_003408469.1 antitoxin Antitoxin
FF952_RS09130 (FF952_09415) 1953887..1955371 + 1485 WP_003904684.1 biotin carboxylase -
FF952_RS09135 (FF952_09420) 1955368..1956615 + 1248 WP_003408476.1 serine hydrolase -
FF952_RS09140 (FF952_09425) 1956658..1957077 - 420 WP_003904685.1 hypothetical protein -
FF952_RS09145 (FF952_09430) 1957067..1957777 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T126587 WP_003408465.1 NZ_CP040689:c1953445-1953056 [Mycobacterium tuberculosis complex sp. N0072]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T126587 NZ_CP040689:c1953445-1953056 [Mycobacterium tuberculosis complex sp. N0072]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT126587 WP_003408469.1 NZ_CP040689:c1953669-1953442 [Mycobacterium tuberculosis complex sp. N0072]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT126587 NZ_CP040689:c1953669-1953442 [Mycobacterium tuberculosis complex sp. N0072]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References