Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1692249..1692865 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag FF952_RS07945 Protein ID WP_003407593.1
Coordinates 1692548..1692865 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag FF952_RS07940 Protein ID WP_003900349.1
Coordinates 1692249..1692551 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS07930 (FF952_08205) 1688135..1689982 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
FF952_RS07935 (FF952_08210) 1689983..1692235 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
FF952_RS07940 (FF952_08215) 1692249..1692551 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
FF952_RS07945 (FF952_08220) 1692548..1692865 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
FF952_RS07950 (FF952_08225) 1692862..1693866 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
FF952_RS07955 (FF952_08230) 1693919..1695208 + 1290 WP_003407599.1 serine hydrolase domain-containing protein -
FF952_RS07960 (FF952_08235) 1695281..1696006 - 726 WP_003898898.1 class I SAM-dependent methyltransferase -
FF952_RS07965 (FF952_08240) 1696112..1696324 - 213 WP_003898900.1 dodecin family protein -
FF952_RS07970 (FF952_08245) 1696385..1696783 + 399 WP_003900351.1 hypothetical protein -
FF952_RS07975 (FF952_08250) 1696828..1697856 + 1029 WP_003903478.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T126585 WP_003407593.1 NZ_CP040689:1692548-1692865 [Mycobacterium tuberculosis complex sp. N0072]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T126585 NZ_CP040689:1692548-1692865 [Mycobacterium tuberculosis complex sp. N0072]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT126585 WP_003900349.1 NZ_CP040689:1692249-1692551 [Mycobacterium tuberculosis complex sp. N0072]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT126585 NZ_CP040689:1692249-1692551 [Mycobacterium tuberculosis complex sp. N0072]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References