Detailed information of TA system TA126582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1391245..1391804
• Replicon: chromosome
• Accession: NZ_CP040689
• Organism: Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: FF952_RS06635
• Protein ID: WP_003898789.1
• Coordinates: 1391245..1391538 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: FF952_RS06640
• Protein ID: WP_003406322.1
• Coordinates: 1391535..1391804 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF952_RS06610 (FF952_06810)	1386838..1387098	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
FF952_RS06615 (FF952_06815)	1387095..1387526	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
FF952_RS06620 (FF952_06820)	1387549..1389237	-	1689	WP_003910308.1	PE family protein	-
FF952_RS06625 (FF952_06830)	1389417..1390277	+	861	WP_003903377.1	glycine betaine ABC transporter substrate-binding protein	-
FF952_RS06630 (FF952_06835)	1390358..1391188	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FF952_RS06635 (FF952_06840)	1391245..1391538	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
FF952_RS06640 (FF952_06845)	1391535..1391804	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FF952_RS06645 (FF952_06850)	1391917..1395612	-	3696	WP_015631286.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
FF952_RS06650 (FF952_06855)	1395754..1396542	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T126582 WP_003898789.1 NZ_CP040689:c1391538-1391245 [Mycobacterium tuberculosis complex sp. N0072]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T126582 NZ_CP040689:c1391538-1391245 [Mycobacterium tuberculosis complex sp. N0072]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT126582 WP_003406322.1 NZ_CP040689:c1391804-1391535 [Mycobacterium tuberculosis complex sp. N0072]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT126582 NZ_CP040689:c1391804-1391535 [Mycobacterium tuberculosis complex sp. N0072]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2