Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1233217..1233848 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag FF952_RS05885 Protein ID WP_003405820.1
Coordinates 1233217..1233528 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag FF952_RS05890 Protein ID WP_003405836.1
Coordinates 1233528..1233848 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS05865 (FF952_06050) 1228698..1230122 - 1425 WP_003405805.1 class II fumarate hydratase -
FF952_RS05870 (FF952_06055) 1230153..1231241 - 1089 WP_017351234.1 class II fructose-bisphosphatase -
FF952_RS05875 (FF952_06060) 1231297..1231941 + 645 WP_003915494.1 DUF4245 domain-containing protein -
FF952_RS05880 (FF952_06065) 1231948..1233105 - 1158 WP_003898727.1 AI-2E family transporter -
FF952_RS05885 (FF952_06070) 1233217..1233528 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
FF952_RS05890 (FF952_06075) 1233528..1233848 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
FF952_RS05895 (FF952_06080) 1233858..1235394 + 1537 Protein_1161 carboxylesterase/lipase family protein -
FF952_RS05900 (FF952_06085) 1235401..1236513 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
FF952_RS05905 (FF952_06090) 1236523..1236780 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
FF952_RS05910 (FF952_06095) 1236770..1238017 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
FF952_RS05915 (FF952_06100) 1238014..1238652 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T126579 WP_003405820.1 NZ_CP040689:c1233528-1233217 [Mycobacterium tuberculosis complex sp. N0072]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T126579 NZ_CP040689:c1233528-1233217 [Mycobacterium tuberculosis complex sp. N0072]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT126579 WP_003405836.1 NZ_CP040689:c1233848-1233528 [Mycobacterium tuberculosis complex sp. N0072]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT126579 NZ_CP040689:c1233848-1233528 [Mycobacterium tuberculosis complex sp. N0072]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References