126569

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 720789..721438 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag FF952_RS03285 Protein ID WP_003403236.1
Coordinates 721043..721438 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag FF952_RS03280 Protein ID WP_003403235.1
Coordinates 720789..721043 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS03255 715914..715997 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
FF952_RS03260 (FF952_03335) 716016..717098 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
FF952_RS03265 (FF952_03340) 717095..718186 + 1092 WP_003900977.1 galactokinase -
FF952_RS03270 (FF952_03350) 718581..719738 + 1158 WP_003903091.1 hypothetical protein -
FF952_RS03275 (FF952_03355) 719749..720696 + 948 WP_003403232.1 DUF732 domain-containing protein -
FF952_RS03280 (FF952_03360) 720789..721043 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
FF952_RS03285 (FF952_03365) 721043..721438 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
FF952_RS03290 (FF952_03370) 721532..722272 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
FF952_RS03295 (FF952_03375) 722404..722664 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FF952_RS03300 (FF952_03380) 722661..723068 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
FF952_RS03305 (FF952_03385) 723140..724291 - 1152 WP_244736125.1 FIST N-terminal domain-containing protein -
FF952_RS03310 (FF952_03390) 724384..726105 - 1722 WP_286450986.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T126569 WP_003403236.1 NZ_CP040689:721043-721438 [Mycobacterium tuberculosis complex sp. N0072]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T126569 NZ_CP040689:721043-721438 [Mycobacterium tuberculosis complex sp. N0072]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT126569 WP_003403235.1 NZ_CP040689:720789-721043 [Mycobacterium tuberculosis complex sp. N0072]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT126569 NZ_CP040689:720789-721043 [Mycobacterium tuberculosis complex sp. N0072]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC2

References