126568

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 715160..715785 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FF952_RS03250 Protein ID WP_003403218.1
Coordinates 715384..715785 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FF952_RS03245 Protein ID WP_003403213.1
Coordinates 715160..715387 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS03220 (FF952_03295) 710339..710560 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FF952_RS03225 (FF952_03300) 710702..711307 + 606 WP_003898526.1 hypothetical protein -
FF952_RS03230 (FF952_03305) 711326..713893 - 2568 WP_031656768.1 SEC-C metal-binding domain-containing protein -
FF952_RS03235 (FF952_03310) 713977..714726 + 750 WP_003898528.1 hypothetical protein -
FF952_RS03240 (FF952_03315) 714723..714965 + 243 WP_003403210.1 hypothetical protein -
FF952_RS03245 (FF952_03325) 715160..715387 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FF952_RS03250 (FF952_03330) 715384..715785 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FF952_RS03255 715914..715997 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
FF952_RS03260 (FF952_03335) 716016..717098 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
FF952_RS03265 (FF952_03340) 717095..718186 + 1092 WP_003900977.1 galactokinase -
FF952_RS03270 (FF952_03350) 718581..719738 + 1158 WP_003903091.1 hypothetical protein -
FF952_RS03275 (FF952_03355) 719749..720696 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-120)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T126568 WP_003403218.1 NZ_CP040689:715384-715785 [Mycobacterium tuberculosis complex sp. N0072]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T126568 NZ_CP040689:715384-715785 [Mycobacterium tuberculosis complex sp. N0072]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTACGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT126568 WP_003403213.1 NZ_CP040689:715160-715387 [Mycobacterium tuberculosis complex sp. N0072]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT126568 NZ_CP040689:715160-715387 [Mycobacterium tuberculosis complex sp. N0072]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQA0


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References