Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 707622..708265 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag FF952_RS03200 Protein ID WP_003403187.1
Coordinates 707864..708265 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag FF952_RS03195 Protein ID WP_003403184.1
Coordinates 707622..707867 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS03160 (FF952_03225) 702902..703432 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FF952_RS03165 (FF952_03230) 703416..704111 - 696 WP_200861092.1 two-component system response regulator TcrA -
FF952_RS03170 (FF952_03235) 704234..704545 + 312 WP_003403164.1 hypothetical protein -
FF952_RS03175 (FF952_03240) 704617..705567 + 951 WP_003907436.1 DUF1259 domain-containing protein -
FF952_RS03180 (FF952_03245) 705808..706392 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
FF952_RS03185 (FF952_03250) 706394..707104 + 711 Protein_631 IS607 family element RNA-guided endonuclease TnpB -
FF952_RS03190 (FF952_03255) 707107..707577 + 471 WP_003898523.1 hypothetical protein -
FF952_RS03195 (FF952_03260) 707622..707867 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FF952_RS03200 (FF952_03265) 707864..708265 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
FF952_RS03205 (FF952_03270) 708256..708435 + 180 Protein_635 hypothetical protein -
FF952_RS03210 (FF952_03285) 708853..709050 - 198 WP_003403191.1 hypothetical protein -
FF952_RS03215 (FF952_03290) 709130..710287 - 1158 Protein_637 hypothetical protein -
FF952_RS03220 (FF952_03295) 710339..710560 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FF952_RS03225 (FF952_03300) 710702..711307 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T126567 WP_003403187.1 NZ_CP040689:707864-708265 [Mycobacterium tuberculosis complex sp. N0072]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T126567 NZ_CP040689:707864-708265 [Mycobacterium tuberculosis complex sp. N0072]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT126567 WP_003403184.1 NZ_CP040689:707622-707867 [Mycobacterium tuberculosis complex sp. N0072]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT126567 NZ_CP040689:707622-707867 [Mycobacterium tuberculosis complex sp. N0072]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References