Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 367433..368076 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag FF952_RS01605 Protein ID WP_003401566.1
Coordinates 367651..368076 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag FF952_RS01600 Protein ID WP_003401563.1
Coordinates 367433..367654 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS01575 (FF952_01605) 362561..363364 - 804 WP_003401540.1 Stf0 family sulphotransferase -
FF952_RS01580 (FF952_01610) 363374..364771 - 1398 WP_003401544.1 sulfatase -
FF952_RS01585 (FF952_01615) 364950..366716 + 1767 WP_286450958.1 PE family protein -
FF952_RS01590 (FF952_01620) 366859..367086 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
FF952_RS01595 (FF952_01625) 367083..367385 + 303 WP_003401560.1 toxin-antitoxin system toxin -
FF952_RS01600 (FF952_01630) 367433..367654 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
FF952_RS01605 (FF952_01635) 367651..368076 + 426 WP_003401566.1 PIN domain nuclease Toxin
FF952_RS01610 (FF952_01640) 368212..368844 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
FF952_RS01615 (FF952_01645) 368841..369749 + 909 WP_003900117.1 protochlorophyllide reductase -
FF952_RS01620 369757..370347 - 591 WP_229298012.1 hypothetical protein -
FF952_RS01625 370340..370390 - 51 Protein_321 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T126561 WP_003401566.1 NZ_CP040689:367651-368076 [Mycobacterium tuberculosis complex sp. N0072]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T126561 NZ_CP040689:367651-368076 [Mycobacterium tuberculosis complex sp. N0072]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT126561 WP_003401563.1 NZ_CP040689:367433-367654 [Mycobacterium tuberculosis complex sp. N0072]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT126561 NZ_CP040689:367433-367654 [Mycobacterium tuberculosis complex sp. N0072]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References