126559

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 366859..367385 Replicon chromosome
Accession NZ_CP040689
Organism Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag FF952_RS01595 Protein ID WP_003401560.1
Coordinates 367083..367385 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag FF952_RS01590 Protein ID WP_003401555.1
Coordinates 366859..367086 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF952_RS01575 (FF952_01605) 362561..363364 - 804 WP_003401540.1 Stf0 family sulphotransferase -
FF952_RS01580 (FF952_01610) 363374..364771 - 1398 WP_003401544.1 sulfatase -
FF952_RS01585 (FF952_01615) 364950..366716 + 1767 WP_286450958.1 PE family protein -
FF952_RS01590 (FF952_01620) 366859..367086 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
FF952_RS01595 (FF952_01625) 367083..367385 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
FF952_RS01600 (FF952_01630) 367433..367654 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
FF952_RS01605 (FF952_01635) 367651..368076 + 426 WP_003401566.1 PIN domain nuclease -
FF952_RS01610 (FF952_01640) 368212..368844 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
FF952_RS01615 (FF952_01645) 368841..369749 + 909 WP_003900117.1 protochlorophyllide reductase -
FF952_RS01620 369757..370347 - 591 WP_229298012.1 hypothetical protein -
FF952_RS01625 370340..370390 - 51 Protein_321 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(6-41)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T126559 WP_003401560.1 NZ_CP040689:367083-367385 [Mycobacterium tuberculosis complex sp. N0072]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T126559 NZ_CP040689:367083-367385 [Mycobacterium tuberculosis complex sp. N0072]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT126559 WP_003401555.1 NZ_CP040689:366859-367086 [Mycobacterium tuberculosis complex sp. N0072]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT126559 NZ_CP040689:366859-367086 [Mycobacterium tuberculosis complex sp. N0072]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References