126554

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3692446..3693120 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FF951_RS17510 Protein ID WP_003417282.1
Coordinates 3692446..3692874 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FF951_RS17515 Protein ID WP_003417286.1
Coordinates 3692878..3693120 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS17485 (FF951_18100) 3688268..3688669 - 402 WP_003417264.1 cytidine deaminase -
FF951_RS17490 (FF951_18105) 3688906..3689244 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
FF951_RS17495 (FF951_18110) 3689241..3689675 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FF951_RS17500 (FF951_18115) 3689804..3691576 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FF951_RS17505 (FF951_18120) 3691576..3692367 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FF951_RS17510 (FF951_18125) 3692446..3692874 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FF951_RS17515 (FF951_18130) 3692878..3693120 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
FF951_RS17520 (FF951_18135) 3693242..3693856 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FF951_RS17525 (FF951_18140) 3693853..3694518 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FF951_RS17530 (FF951_18145) 3694519..3695052 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FF951_RS17535 (FF951_18150) 3695049..3695423 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FF951_RS17540 (FF951_18155) 3695520..3696656 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-141)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T126554 WP_003417282.1 NZ_CP040688:c3692874-3692446 [Mycobacterium tuberculosis complex sp. N0052]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T126554 NZ_CP040688:c3692874-3692446 [Mycobacterium tuberculosis complex sp. N0052]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT126554 WP_003417286.1 NZ_CP040688:c3693120-3692878 [Mycobacterium tuberculosis complex sp. N0052]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT126554 NZ_CP040688:c3693120-3692878 [Mycobacterium tuberculosis complex sp. N0052]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0


Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References