Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3057088..3057767 | Replicon | chromosome |
| Accession | NZ_CP040688 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0052 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | FF951_RS14545 | Protein ID | WP_003414059.1 |
| Coordinates | 3057088..3057504 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | FF951_RS14550 | Protein ID | WP_003414061.1 |
| Coordinates | 3057501..3057767 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF951_RS14525 (FF951_15020) | 3053140..3054042 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| FF951_RS14530 (FF951_15025) | 3054111..3054863 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| FF951_RS14535 (FF951_15030) | 3055107..3055382 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| FF951_RS14540 (FF951_15035) | 3055379..3057001 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
| FF951_RS14545 (FF951_15040) | 3057088..3057504 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| FF951_RS14550 (FF951_15045) | 3057501..3057767 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| FF951_RS14555 (FF951_15050) | 3057793..3058188 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF951_RS14560 (FF951_15055) | 3058185..3058454 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| FF951_RS14565 (FF951_15060) | 3058464..3059558 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| FF951_RS14570 (FF951_15065) | 3059555..3059974 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| FF951_RS14575 | 3059973..3060047 | + | 75 | Protein_2876 | hypothetical protein | - |
| FF951_RS14580 (FF951_15070) | 3060048..3060527 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| FF951_RS14585 (FF951_15075) | 3060598..3061398 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| FF951_RS14590 (FF951_15080) | 3061554..3062291 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T126546 WP_003414059.1 NZ_CP040688:c3057504-3057088 [Mycobacterium tuberculosis complex sp. N0052]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T126546 NZ_CP040688:c3057504-3057088 [Mycobacterium tuberculosis complex sp. N0052]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT126546 WP_003414061.1 NZ_CP040688:c3057767-3057501 [Mycobacterium tuberculosis complex sp. N0052]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT126546 NZ_CP040688:c3057767-3057501 [Mycobacterium tuberculosis complex sp. N0052]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|