Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | unclassified/- |
| Location | 2963245..2963893 | Replicon | chromosome |
| Accession | NZ_CP040688 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0052 | ||
Toxin (Protein)
| Gene name | novel[antitoxin] | Uniprot ID | P9WJ12 |
| Locus tag | FF951_RS14010 | Protein ID | WP_003899414.1 |
| Coordinates | 2963245..2963568 (-) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
| Locus tag | FF951_RS14015 | Protein ID | WP_003899415.1 |
| Coordinates | 2963648..2963893 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF951_RS13980 (FF951_14445) | 2958568..2959566 | + | 999 | WP_003900538.1 | tyrosine-type recombinase/integrase | - |
| FF951_RS13985 (FF951_14450) | 2959580..2960044 | + | 465 | WP_003900539.1 | ParB N-terminal domain-containing protein | - |
| FF951_RS13990 (FF951_14455) | 2960032..2960283 | + | 252 | WP_003908028.1 | hypothetical protein | - |
| FF951_RS13995 (FF951_14460) | 2960454..2961893 | - | 1440 | WP_003901443.1 | phage major capsid protein | - |
| FF951_RS14000 (FF951_14465) | 2961901..2962434 | - | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
| FF951_RS14005 (FF951_14470) | 2962587..2963078 | - | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
| FF951_RS14010 (FF951_14475) | 2963245..2963568 | - | 324 | WP_003899414.1 | type II toxin-antitoxin system toxin | Toxin |
| FF951_RS14015 (FF951_14480) | 2963648..2963893 | - | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
| FF951_RS14020 (FF951_14485) | 2963890..2965317 | - | 1428 | WP_003899416.1 | DUF3631 domain-containing protein | - |
| FF951_RS14025 (FF951_14490) | 2965319..2965711 | - | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
| FF951_RS14030 (FF951_14495) | 2965708..2965968 | - | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
| FF951_RS14035 (FF951_14500) | 2965985..2966347 | - | 363 | WP_003900543.1 | hypothetical protein | - |
| FF951_RS14040 (FF951_14505) | 2966350..2967477 | - | 1128 | WP_003899420.1 | site-specific integrase | - |
| FF951_RS14045 (FF951_14510) | 2967622..2967849 | - | 228 | WP_003899421.1 | hypothetical protein | - |
| FF951_RS14050 (FF951_14515) | 2967846..2968235 | - | 390 | WP_003899422.1 | hypothetical protein | - |
| FF951_RS14055 (FF951_14520) | 2968141..2968413 | + | 273 | WP_003900544.1 | hypothetical protein | - |
| FF951_RS14060 (FF951_14525) | 2968512..2968745 | + | 234 | WP_003413717.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2958568..2967477 | 8909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12359.82 Da Isoelectric Point: 8.6717
>T126545 WP_003899414.1 NZ_CP040688:c2963568-2963245 [Mycobacterium tuberculosis complex sp. N0052]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
Download Length: 324 bp
>T126545 NZ_CP040688:c2963568-2963245 [Mycobacterium tuberculosis complex sp. N0052]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT126545 WP_003899415.1 NZ_CP040688:c2963893-2963648 [Mycobacterium tuberculosis complex sp. N0052]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT126545 NZ_CP040688:c2963893-2963648 [Mycobacterium tuberculosis complex sp. N0052]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A045IHC4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A806JR81 |