Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2796107..2796759 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag FF951_RS13160 Protein ID WP_003412752.1
Coordinates 2796334..2796759 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag FF951_RS13155 Protein ID WP_003412749.1
Coordinates 2796107..2796328 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS13140 (FF951_13550) 2794347..2794553 - 207 WP_003899347.1 hypothetical protein -
FF951_RS13145 (FF951_13555) 2794689..2795312 + 624 WP_003900858.1 TIGR00725 family protein -
FF951_RS13150 (FF951_13560) 2795302..2796054 + 753 WP_003901416.1 hypothetical protein -
FF951_RS13155 (FF951_13565) 2796107..2796328 + 222 WP_003412749.1 antitoxin Antitoxin
FF951_RS13160 (FF951_13570) 2796334..2796759 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
FF951_RS13165 (FF951_13575) 2796782..2797963 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
FF951_RS13170 (FF951_13580) 2797960..2799006 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
FF951_RS13175 (FF951_13585) 2799017..2800120 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
FF951_RS13180 (FF951_13590) 2800379..2801200 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
FF951_RS13185 (FF951_13595) 2801197..2801754 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T126539 WP_003412752.1 NZ_CP040688:2796334-2796759 [Mycobacterium tuberculosis complex sp. N0052]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T126539 NZ_CP040688:2796334-2796759 [Mycobacterium tuberculosis complex sp. N0052]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT126539 WP_003412749.1 NZ_CP040688:2796107-2796328 [Mycobacterium tuberculosis complex sp. N0052]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT126539 NZ_CP040688:2796107-2796328 [Mycobacterium tuberculosis complex sp. N0052]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References