Detailed information of TA system TA126538

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2394562..2395091
• Replicon: chromosome
• Accession: NZ_CP040688
• Organism: Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: FF951_RS11245
• Protein ID: WP_003411124.1
• Coordinates: 2394562..2394879 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: FF951_RS11250
• Protein ID: WP_003411127.1
• Coordinates: 2394876..2395091 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF951_RS11215 (FF951_11580)	2389583..2390659	+	1077	WP_003411110.1	hypothetical protein	-
FF951_RS11220 (FF951_11585)	2390656..2390937	+	282	WP_003411112.1	DUF5703 family protein	-
FF951_RS11225 (FF951_11590)	2390973..2392046	+	1074	WP_003901338.1	quinone-dependent dihydroorotate dehydrogenase	-
FF951_RS11230 (FF951_11595)	2392051..2392581	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
FF951_RS11235 (FF951_11600)	2392629..2393975	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
FF951_RS11245 (FF951_11610)	2394562..2394879	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FF951_RS11250 (FF951_11615)	2394876..2395091	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
FF951_RS11255 (FF951_11620)	2395346..2396404	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
FF951_RS11260 (FF951_11625)	2396534..2396890	-	357	WP_003411130.1	hypothetical protein	-
FF951_RS11265 (FF951_11630)	2396985..2397767	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
FF951_RS11270 (FF951_11635)	2398035..2398325	-	291	WP_003900476.1	YggT family protein	-
FF951_RS11275 (FF951_11640)	2398487..2399143	-	657	WP_003411133.1	cell division protein SepF	-
FF951_RS11280 (FF951_11645)	2399209..2399985	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T126538 WP_003411124.1 NZ_CP040688:c2394879-2394562 [Mycobacterium tuberculosis complex sp. N0052]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T126538 NZ_CP040688:c2394879-2394562 [Mycobacterium tuberculosis complex sp. N0052]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT126538 WP_003411127.1 NZ_CP040688:c2395091-2394876 [Mycobacterium tuberculosis complex sp. N0052]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT126538 NZ_CP040688:c2395091-2394876 [Mycobacterium tuberculosis complex sp. N0052]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4