126537

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2356284..2356979 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag FF951_RS11030 Protein ID WP_003410811.1
Coordinates 2356284..2356718 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag FF951_RS11035 Protein ID WP_003410814.1
Coordinates 2356725..2356979 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS11020 (FF951_11385) 2352438..2355479 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
FF951_RS11025 (FF951_11390) 2355472..2356305 + 834 WP_003899172.1 SWIM zinc finger family protein -
FF951_RS11030 (FF951_11395) 2356284..2356718 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
FF951_RS11035 (FF951_11400) 2356725..2356979 - 255 WP_003410814.1 antitoxin Antitoxin
FF951_RS11040 (FF951_11405) 2356995..2357252 - 258 WP_003410816.1 hypothetical protein -
FF951_RS11045 (FF951_11415) 2357786..2359047 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FF951_RS11050 (FF951_11420) 2359557..2359853 + 297 WP_003410820.1 PE family protein -
FF951_RS11055 (FF951_11425) 2359909..2360640 + 732 WP_003900467.1 PPE family protein -
FF951_RS11060 (FF951_11430) 2361180..2361926 - 747 WP_003901330.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T126537 WP_003410811.1 NZ_CP040688:c2356718-2356284 [Mycobacterium tuberculosis complex sp. N0052]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T126537 NZ_CP040688:c2356718-2356284 [Mycobacterium tuberculosis complex sp. N0052]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT126537 WP_003410814.1 NZ_CP040688:c2356979-2356725 [Mycobacterium tuberculosis complex sp. N0052]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT126537 NZ_CP040688:c2356979-2356725 [Mycobacterium tuberculosis complex sp. N0052]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References