Detailed information of TA system TA126534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2242445..2243071
• Replicon: chromosome
• Accession: NZ_CP040688
• Organism: Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P64926
• Locus tag: FF951_RS10525
• Protein ID: WP_003410075.1
• Coordinates: 2242673..2243071 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A806JLL8
• Locus tag: FF951_RS10520
• Protein ID: WP_003911750.1
• Coordinates: 2242445..2242672 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF951_RS10510 (FF951_10855)	2240484..2240828	-	345	WP_003410065.1	ferredoxin family protein	-
FF951_RS10515 (FF951_10860)	2241017..2242186	-	1170	WP_003899126.1	ATP-binding protein	-
FF951_RS10520 (FF951_10865)	2242445..2242672	+	228	WP_003911750.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FF951_RS10525 (FF951_10870)	2242673..2243071	+	399	WP_003410075.1	PIN domain nuclease	Toxin
FF951_RS10530 (FF951_10875)	2243254..2243685	-	432	WP_003410078.1	MarR family winged helix-turn-helix transcriptional regulator	-
FF951_RS10535 (FF951_10880)	2243786..2244220	+	435	WP_003914358.1	DUF1398 domain-containing protein	-
FF951_RS10540 (FF951_10895)	2244657..2244836	-	180	Protein_2083	hypothetical protein	-
FF951_RS10545 (FF951_10900)	2244924..2245544	+	621	WP_003410086.1	IS110 family transposase	-
FF951_RS10550 (FF951_10905)	2245498..2246088	+	591	WP_003899131.1	IS110 family transposase	-
FF951_RS10555 (FF951_10910)	2246216..2247472	-	1257	WP_286449282.1	HNH endonuclease signature motif containing protein	-
FF951_RS10560 (FF951_10920)	2247826..2248026	+	201	Protein_2087	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-120)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-43)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14731.02 Da
• Isoelectric Point: 6.7067

>T126534 WP_003410075.1 NZ_CP040688:2242673-2243071 [Mycobacterium tuberculosis complex sp. N0052]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Nucleotide

• Length: 399 bp

>T126534 NZ_CP040688:2242673-2243071 [Mycobacterium tuberculosis complex sp. N0052]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8346.16 Da
• Isoelectric Point: 4.1621

>AT126534 WP_003911750.1 NZ_CP040688:2242445-2242672 [Mycobacterium tuberculosis complex sp. N0052]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Nucleotide

• Length: 228 bp

>AT126534 NZ_CP040688:2242445-2242672 [Mycobacterium tuberculosis complex sp. N0052]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Structures

Toxin

• PDB: 4CHG

Antitoxin

• AlphaFold DB: A0A806JLL8