Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2217140..2218038 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FF951_RS10400 Protein ID WP_003410001.1
Coordinates 2217140..2217700 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FF951_RS10405 Protein ID WP_003410003.1
Coordinates 2217697..2218038 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS10370 (FF951_10715) 2212309..2212962 - 654 WP_003409976.1 cutinase Cfp21 -
FF951_RS10375 (FF951_10720) 2213077..2213307 + 231 WP_003409980.1 DUF167 domain-containing protein -
FF951_RS10380 (FF951_10725) 2213392..2214303 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FF951_RS10385 (FF951_10730) 2214412..2215011 + 600 WP_286449251.1 L-lysine exporter -
FF951_RS10390 (FF951_10735) 2215427..2215855 + 429 WP_003409992.1 cellulose-binding protein -
FF951_RS10395 (FF951_10740) 2216081..2216620 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FF951_RS10400 (FF951_10750) 2217140..2217700 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
FF951_RS10405 (FF951_10755) 2217697..2218038 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
FF951_RS10410 (FF951_10760) 2218124..2218381 + 258 WP_003410006.1 hypothetical protein -
FF951_RS10415 (FF951_10765) 2218282..2218617 - 336 WP_003410009.1 dehydrogenase -
FF951_RS10420 (FF951_10770) 2218706..2219050 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
FF951_RS10425 (FF951_10775) 2219044..2219292 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
FF951_RS10430 (FF951_10780) 2219392..2221707 - 2316 WP_003899120.1 cation transporter ATPase CptG -
FF951_RS10435 (FF951_10785) 2221704..2221976 - 273 WP_003410017.1 DUF1490 family protein -
FF951_RS10440 (FF951_10790) 2222029..2222385 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T126532 WP_003410001.1 NZ_CP040688:c2217700-2217140 [Mycobacterium tuberculosis complex sp. N0052]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T126532 NZ_CP040688:c2217700-2217140 [Mycobacterium tuberculosis complex sp. N0052]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT126532 WP_003410003.1 NZ_CP040688:c2218038-2217697 [Mycobacterium tuberculosis complex sp. N0052]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT126532 NZ_CP040688:c2218038-2217697 [Mycobacterium tuberculosis complex sp. N0052]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References