Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2183585..2184129 | Replicon | chromosome |
| Accession | NZ_CP040688 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0052 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FF951_RS10200 | Protein ID | WP_003409896.1 |
| Coordinates | 2183585..2183881 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FF951_RS10205 | Protein ID | WP_003409899.1 |
| Coordinates | 2183878..2184129 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF951_RS10145 (FF951_10475) | 2178618..2178968 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| FF951_RS10150 (FF951_10480) | 2178979..2179881 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| FF951_RS10155 (FF951_10485) | 2179902..2180093 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FF951_RS10160 (FF951_10490) | 2180094..2180390 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FF951_RS10165 (FF951_10495) | 2180630..2180845 | + | 216 | WP_003409878.1 | antitoxin | - |
| FF951_RS10170 (FF951_10500) | 2180842..2181153 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF951_RS10175 | 2181127..2181648 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FF951_RS10180 (FF951_10510) | 2181623..2182000 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FF951_RS10185 (FF951_10515) | 2182042..2182491 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FF951_RS10190 (FF951_10520) | 2182488..2183033 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FF951_RS10195 (FF951_10525) | 2182922..2183536 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FF951_RS10200 (FF951_10530) | 2183585..2183881 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FF951_RS10205 (FF951_10535) | 2183878..2184129 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FF951_RS10210 (FF951_10540) | 2184116..2184610 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FF951_RS10215 (FF951_10545) | 2184770..2185177 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF951_RS10220 (FF951_10550) | 2185181..2185453 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FF951_RS10225 (FF951_10555) | 2185486..2186706 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FF951_RS10230 (FF951_10570) | 2187605..2188402 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T126530 WP_003409896.1 NZ_CP040688:c2183881-2183585 [Mycobacterium tuberculosis complex sp. N0052]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T126530 NZ_CP040688:c2183881-2183585 [Mycobacterium tuberculosis complex sp. N0052]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT126530 WP_003409899.1 NZ_CP040688:c2184129-2183878 [Mycobacterium tuberculosis complex sp. N0052]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT126530 NZ_CP040688:c2184129-2183878 [Mycobacterium tuberculosis complex sp. N0052]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |