Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1956636..1957096 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag FF951_RS09135 Protein ID WP_003898996.1
Coordinates 1956848..1957096 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag FF951_RS09130 Protein ID WP_003408528.1
Coordinates 1956636..1956848 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS09115 (FF951_09390) 1953114..1954301 - 1188 WP_003898992.1 nitrate transporter NarK -
FF951_RS09120 (FF951_09395) 1954588..1954872 + 285 WP_003408522.1 DUF1876 domain-containing protein -
FF951_RS09125 (FF951_09400) 1954886..1956568 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
FF951_RS09130 (FF951_09405) 1956636..1956848 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FF951_RS09135 (FF951_09410) 1956848..1957096 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
FF951_RS09140 (FF951_09415) 1957104..1957841 + 738 WP_003898997.1 hypothetical protein -
FF951_RS09145 (FF951_09420) 1957935..1959635 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
FF951_RS09150 (FF951_09425) 1959920..1960321 - 402 WP_003408538.1 hypothetical protein -
FF951_RS09155 (FF951_09430) 1960311..1960922 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T126527 WP_003898996.1 NZ_CP040688:1956848-1957096 [Mycobacterium tuberculosis complex sp. N0052]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T126527 NZ_CP040688:1956848-1957096 [Mycobacterium tuberculosis complex sp. N0052]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT126527 WP_003408528.1 NZ_CP040688:1956636-1956848 [Mycobacterium tuberculosis complex sp. N0052]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT126527 NZ_CP040688:1956636-1956848 [Mycobacterium tuberculosis complex sp. N0052]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References