Detailed information of TA system TA126526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1935793..1936406
• Replicon: chromosome
• Accession: NZ_CP040688
• Organism: Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WFA2
• Locus tag: FF951_RS09020
• Protein ID: WP_003408465.1
• Coordinates: 1935793..1936182 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ52
• Locus tag: FF951_RS09025
• Protein ID: WP_003408469.1
• Coordinates: 1936179..1936406 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF951_RS08985 (FF951_09260)	1931422..1932336	+	915	WP_003898985.1	3-hydroxyacyl-CoA dehydrogenase family protein	-
FF951_RS08990 (FF951_09265)	1932339..1933169	+	831	WP_003408448.1	cyclase family protein	-
FF951_RS08995 (FF951_09270)	1933169..1933519	+	351	WP_003898986.1	cupin domain-containing protein	-
FF951_RS09000 (FF951_09275)	1933572..1934390	+	819	WP_003408456.1	3-keto-5-aminohexanoate cleavage protein	-
FF951_RS09005 (FF951_09280)	1934404..1935183	+	780	WP_003408460.1	IclR family transcriptional regulator	-
FF951_RS09015	1935614..1935745	+	132	Protein_1778	IS3 family transposase	-
FF951_RS09020 (FF951_09290)	1935793..1936182	-	390	WP_003408465.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF951_RS09025 (FF951_09295)	1936179..1936406	-	228	WP_003408469.1	antitoxin	Antitoxin
FF951_RS09030 (FF951_09300)	1936624..1938108	+	1485	WP_286450606.1	biotin carboxylase	-
FF951_RS09035 (FF951_09305)	1938105..1939352	+	1248	WP_003408476.1	serine hydrolase	-
FF951_RS09040 (FF951_09310)	1939395..1939814	-	420	WP_003408483.1	hypothetical protein	-
FF951_RS09045 (FF951_09315)	1939804..1940514	-	711	WP_003408486.1	winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-116)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 13817.98 Da
• Isoelectric Point: 7.0612

>T126526 WP_003408465.1 NZ_CP040688:c1936182-1935793 [Mycobacterium tuberculosis complex sp. N0052]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Nucleotide

• Length: 390 bp

>T126526 NZ_CP040688:c1936182-1935793 [Mycobacterium tuberculosis complex sp. N0052]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8226.39 Da
• Isoelectric Point: 4.3313

>AT126526 WP_003408469.1 NZ_CP040688:c1936406-1936179 [Mycobacterium tuberculosis complex sp. N0052]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Nucleotide

• Length: 228 bp

>AT126526 NZ_CP040688:c1936406-1936179 [Mycobacterium tuberculosis complex sp. N0052]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BUI9

Antitoxin

• AlphaFold DB: A0A7U4FAN9