Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1935793..1936406 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag FF951_RS09020 Protein ID WP_003408465.1
Coordinates 1935793..1936182 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FF951_RS09025 Protein ID WP_003408469.1
Coordinates 1936179..1936406 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS08985 (FF951_09260) 1931422..1932336 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
FF951_RS08990 (FF951_09265) 1932339..1933169 + 831 WP_003408448.1 cyclase family protein -
FF951_RS08995 (FF951_09270) 1933169..1933519 + 351 WP_003898986.1 cupin domain-containing protein -
FF951_RS09000 (FF951_09275) 1933572..1934390 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
FF951_RS09005 (FF951_09280) 1934404..1935183 + 780 WP_003408460.1 IclR family transcriptional regulator -
FF951_RS09015 1935614..1935745 + 132 Protein_1778 IS3 family transposase -
FF951_RS09020 (FF951_09290) 1935793..1936182 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
FF951_RS09025 (FF951_09295) 1936179..1936406 - 228 WP_003408469.1 antitoxin Antitoxin
FF951_RS09030 (FF951_09300) 1936624..1938108 + 1485 WP_286450606.1 biotin carboxylase -
FF951_RS09035 (FF951_09305) 1938105..1939352 + 1248 WP_003408476.1 serine hydrolase -
FF951_RS09040 (FF951_09310) 1939395..1939814 - 420 WP_003408483.1 hypothetical protein -
FF951_RS09045 (FF951_09315) 1939804..1940514 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T126526 WP_003408465.1 NZ_CP040688:c1936182-1935793 [Mycobacterium tuberculosis complex sp. N0052]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T126526 NZ_CP040688:c1936182-1935793 [Mycobacterium tuberculosis complex sp. N0052]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT126526 WP_003408469.1 NZ_CP040688:c1936406-1936179 [Mycobacterium tuberculosis complex sp. N0052]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT126526 NZ_CP040688:c1936406-1936179 [Mycobacterium tuberculosis complex sp. N0052]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References