Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1684253..1684869 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag FF951_RS07920 Protein ID WP_003407593.1
Coordinates 1684552..1684869 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag FF951_RS07915 Protein ID WP_003900349.1
Coordinates 1684253..1684555 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS07905 (FF951_08160) 1680139..1681986 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
FF951_RS07910 (FF951_08165) 1681987..1684239 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
FF951_RS07915 (FF951_08170) 1684253..1684555 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
FF951_RS07920 (FF951_08175) 1684552..1684869 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
FF951_RS07925 (FF951_08180) 1684866..1685870 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
FF951_RS07930 (FF951_08185) 1685923..1687212 + 1290 WP_003902090.1 serine hydrolase domain-containing protein -
FF951_RS07935 (FF951_08190) 1687285..1688010 - 726 WP_003898898.1 class I SAM-dependent methyltransferase -
FF951_RS07940 (FF951_08195) 1688116..1688328 - 213 WP_003898900.1 dodecin family protein -
FF951_RS07945 (FF951_08200) 1688389..1688787 + 399 WP_003900351.1 hypothetical protein -
FF951_RS07950 (FF951_08205) 1688832..1689860 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T126524 WP_003407593.1 NZ_CP040688:1684552-1684869 [Mycobacterium tuberculosis complex sp. N0052]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T126524 NZ_CP040688:1684552-1684869 [Mycobacterium tuberculosis complex sp. N0052]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT126524 WP_003900349.1 NZ_CP040688:1684253-1684555 [Mycobacterium tuberculosis complex sp. N0052]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT126524 NZ_CP040688:1684253-1684555 [Mycobacterium tuberculosis complex sp. N0052]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References