Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1570373..1571028 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag FF951_RS07410 Protein ID WP_003898861.1
Coordinates 1570373..1570774 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag FF951_RS07415 Protein ID WP_003407272.1
Coordinates 1570771..1571028 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS07395 (FF951_07620) 1565845..1567230 - 1386 WP_003407260.1 cytochrome P450 -
FF951_RS07400 (FF951_07625) 1567308..1568342 + 1035 WP_003407264.1 AraC family transcriptional regulator -
FF951_RS07405 (FF951_07630) 1568388..1570118 - 1731 WP_009940170.1 PE family protein -
FF951_RS07410 (FF951_07635) 1570373..1570774 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
FF951_RS07415 (FF951_07640) 1570771..1571028 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
FF951_RS07420 (FF951_07645) 1571111..1572070 - 960 WP_003407276.1 alpha/beta hydrolase -
FF951_RS07425 (FF951_07650) 1572095..1573057 - 963 WP_003407279.1 alpha/beta hydrolase -
FF951_RS07430 (FF951_07655) 1573056..1573793 + 738 WP_031647000.1 lysoplasmalogenase -
FF951_RS07435 (FF951_07660) 1573874..1575841 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T126523 WP_003898861.1 NZ_CP040688:c1570774-1570373 [Mycobacterium tuberculosis complex sp. N0052]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T126523 NZ_CP040688:c1570774-1570373 [Mycobacterium tuberculosis complex sp. N0052]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT126523 WP_003407272.1 NZ_CP040688:c1571028-1570771 [Mycobacterium tuberculosis complex sp. N0052]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT126523 NZ_CP040688:c1571028-1570771 [Mycobacterium tuberculosis complex sp. N0052]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References