Detailed information of TA system TA126521

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1384724..1385283
• Replicon: chromosome
• Accession: NZ_CP040688
• Organism: Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: FF951_RS06605
• Protein ID: WP_003898789.1
• Coordinates: 1384724..1385017 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: FF951_RS06610
• Protein ID: WP_003406322.1
• Coordinates: 1385014..1385283 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF951_RS06580 (FF951_06775)	1380422..1380682	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
FF951_RS06585 (FF951_06780)	1380679..1381110	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
FF951_RS06590 (FF951_06785)	1381133..1382716	-	1584	WP_009940130.1	PE family protein	-
FF951_RS06595 (FF951_06795)	1382896..1383756	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
FF951_RS06600 (FF951_06800)	1383837..1384667	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FF951_RS06605 (FF951_06805)	1384724..1385017	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
FF951_RS06610 (FF951_06810)	1385014..1385283	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FF951_RS06615 (FF951_06815)	1385396..1389091	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
FF951_RS06620 (FF951_06820)	1389233..1390021	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T126521 WP_003898789.1 NZ_CP040688:c1385017-1384724 [Mycobacterium tuberculosis complex sp. N0052]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T126521 NZ_CP040688:c1385017-1384724 [Mycobacterium tuberculosis complex sp. N0052]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT126521 WP_003406322.1 NZ_CP040688:c1385283-1385014 [Mycobacterium tuberculosis complex sp. N0052]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT126521 NZ_CP040688:c1385283-1385014 [Mycobacterium tuberculosis complex sp. N0052]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2