Detailed information of TA system TA126520

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1380422..1381110
• Replicon: chromosome
• Accession: NZ_CP040688
• Organism: Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FF951_RS06585
• Protein ID: WP_003406304.1
• Coordinates: 1380679..1381110 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FF951_RS06580
• Protein ID: WP_003406302.1
• Coordinates: 1380422..1380682 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF951_RS06560 (FF951_06755)	1375999..1376823	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FF951_RS06565 (FF951_06760)	1376828..1378009	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FF951_RS06570 (FF951_06765)	1378086..1379186	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FF951_RS06575 (FF951_06770)	1379357..1380346	+	990	WP_003406301.1	malate dehydrogenase	-
FF951_RS06580 (FF951_06775)	1380422..1380682	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FF951_RS06585 (FF951_06780)	1380679..1381110	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF951_RS06590 (FF951_06785)	1381133..1382716	-	1584	WP_009940130.1	PE family protein	-
FF951_RS06595 (FF951_06795)	1382896..1383756	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
FF951_RS06600 (FF951_06800)	1383837..1384667	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FF951_RS06605 (FF951_06805)	1384724..1385017	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FF951_RS06610 (FF951_06810)	1385014..1385283	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T126520 WP_003406304.1 NZ_CP040688:1380679-1381110 [Mycobacterium tuberculosis complex sp. N0052]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T126520 NZ_CP040688:1380679-1381110 [Mycobacterium tuberculosis complex sp. N0052]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT126520 WP_003406302.1 NZ_CP040688:1380422-1380682 [Mycobacterium tuberculosis complex sp. N0052]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT126520 NZ_CP040688:1380422-1380682 [Mycobacterium tuberculosis complex sp. N0052]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6