Detailed information of TA system TA126511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 751166..751706
• Replicon: chromosome
• Accession: NZ_CP040688
• Organism: Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: P9WII0
• Locus tag: FF951_RS03450
• Protein ID: WP_003403376.1
• Coordinates: 751166..751474 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: G0TQE0
• Locus tag: FF951_RS03455
• Protein ID: WP_003403381.1
• Coordinates: 751461..751706 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF951_RS03425 (FF951_03500)	746481..747986	+	1506	WP_003403360.1	carotenoid cleavage oxygenase	-
FF951_RS03430 (FF951_03505)	748067..749077	+	1011	WP_003911248.1	ABC transporter ATP-binding protein	-
FF951_RS03435 (FF951_03510)	749465..749848	-	384	WP_003403365.1	ribonuclease VapC6	-
FF951_RS03440 (FF951_03515)	749943..750098	-	156	WP_003403368.1	type II toxin-antitoxin system VapB family antitoxin	-
FF951_RS03445 (FF951_03520)	750174..750890	-	717	WP_003403371.1	CPBP family intramembrane metalloprotease	-
FF951_RS03450 (FF951_03525)	751166..751474	-	309	WP_003403376.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FF951_RS03455 (FF951_03530)	751461..751706	-	246	WP_003403381.1	ribbon-helix-helix protein, CopG family	Antitoxin
FF951_RS03460 (FF951_03535)	751816..752253	-	438	WP_003403386.1	type II toxin-antitoxin system VapC family toxin	-
FF951_RS03465 (FF951_03540)	752250..752504	-	255	WP_003911263.1	antitoxin VapB7	-
FF951_RS03470 (FF951_03545)	752618..754981	+	2364	WP_003901895.1	arylsulfatase AtsD	-
FF951_RS03475 (FF951_03550)	755044..755370	+	327	WP_003403401.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FF951_RS03480 (FF951_03555)	755282..755620	+	339	WP_003403405.1	PIN domain-containing protein	-
FF951_RS03485 (FF951_03560)	755617..755790	+	174	WP_003898549.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-101)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11320.10 Da
• Isoelectric Point: 11.6554

>T126511 WP_003403376.1 NZ_CP040688:c751474-751166 [Mycobacterium tuberculosis complex sp. N0052]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Nucleotide

• Length: 309 bp

>T126511 NZ_CP040688:c751474-751166 [Mycobacterium tuberculosis complex sp. N0052]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9169.01 Da
• Isoelectric Point: 4.2070

>AT126511 WP_003403381.1 NZ_CP040688:c751706-751461 [Mycobacterium tuberculosis complex sp. N0052]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Nucleotide

• Length: 246 bp

>AT126511 NZ_CP040688:c751706-751461 [Mycobacterium tuberculosis complex sp. N0052]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BSE5

Antitoxin

• AlphaFold DB: G0TQE0