Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 749465..750098 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag FF951_RS03435 Protein ID WP_003403365.1
Coordinates 749465..749848 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag FF951_RS03440 Protein ID WP_003403368.1
Coordinates 749943..750098 (-) Length 52 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS03410 (FF951_03485) 744757..745293 + 537 WP_003403341.1 50S ribosomal protein L10 -
FF951_RS03415 (FF951_03490) 745330..745722 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
FF951_RS03420 (FF951_03495) 745715..746410 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
FF951_RS03425 (FF951_03500) 746481..747986 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
FF951_RS03430 (FF951_03505) 748067..749077 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FF951_RS03435 (FF951_03510) 749465..749848 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
FF951_RS03440 (FF951_03515) 749943..750098 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FF951_RS03445 (FF951_03520) 750174..750890 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FF951_RS03450 (FF951_03525) 751166..751474 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FF951_RS03455 (FF951_03530) 751461..751706 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
FF951_RS03460 (FF951_03535) 751816..752253 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
FF951_RS03465 (FF951_03540) 752250..752504 - 255 WP_003911263.1 antitoxin VapB7 -
FF951_RS03470 (FF951_03545) 752618..754981 + 2364 WP_003901895.1 arylsulfatase AtsD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(3-44)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T126510 WP_003403365.1 NZ_CP040688:c749848-749465 [Mycobacterium tuberculosis complex sp. N0052]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T126510 NZ_CP040688:c749848-749465 [Mycobacterium tuberculosis complex sp. N0052]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT126510 WP_003403368.1 NZ_CP040688:c750098-749943 [Mycobacterium tuberculosis complex sp. N0052]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT126510 NZ_CP040688:c750098-749943 [Mycobacterium tuberculosis complex sp. N0052]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQD6


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References