Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 706731..707356 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FF951_RS03215 Protein ID WP_003403218.1
Coordinates 706955..707356 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FF951_RS03210 Protein ID WP_003403213.1
Coordinates 706731..706958 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS03185 (FF951_03250) 701910..702131 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FF951_RS03190 (FF951_03255) 702273..702878 + 606 WP_003898526.1 hypothetical protein -
FF951_RS03195 (FF951_03260) 702897..705464 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
FF951_RS03200 (FF951_03265) 705548..706297 + 750 WP_003898528.1 hypothetical protein -
FF951_RS03205 (FF951_03270) 706294..706536 + 243 WP_003403210.1 hypothetical protein -
FF951_RS03210 (FF951_03280) 706731..706958 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FF951_RS03215 (FF951_03285) 706955..707356 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FF951_RS03220 707485..707568 + 84 Protein_638 galactose-1-phosphate uridylyltransferase -
FF951_RS03225 707587..708668 + 1082 Protein_639 galactose-1-phosphate uridylyltransferase -
FF951_RS03230 (FF951_03300) 708665..709756 + 1092 WP_003900977.1 galactokinase -
FF951_RS03235 (FF951_03310) 710150..711214 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
FF951_RS03240 (FF951_03315) 711318..712265 + 948 WP_016810166.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T126507 WP_003403218.1 NZ_CP040688:706955-707356 [Mycobacterium tuberculosis complex sp. N0052]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T126507 NZ_CP040688:706955-707356 [Mycobacterium tuberculosis complex sp. N0052]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT126507 WP_003403213.1 NZ_CP040688:706731-706958 [Mycobacterium tuberculosis complex sp. N0052]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT126507 NZ_CP040688:706731-706958 [Mycobacterium tuberculosis complex sp. N0052]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References