Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 699193..699836 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag FF951_RS03165 Protein ID WP_003403187.1
Coordinates 699435..699836 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag FF951_RS03160 Protein ID WP_003403184.1
Coordinates 699193..699438 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS03125 (FF951_03180) 694473..695003 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FF951_RS03130 (FF951_03185) 694987..695682 - 696 WP_003918099.1 two-component system response regulator TcrA -
FF951_RS03135 (FF951_03190) 695805..696116 + 312 WP_003403164.1 hypothetical protein -
FF951_RS03140 (FF951_03195) 696188..697138 + 951 WP_003900184.1 DUF1259 domain-containing protein -
FF951_RS03145 (FF951_03200) 697379..697963 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
FF951_RS03150 (FF951_03205) 697965..698675 + 711 Protein_624 IS607 family element RNA-guided endonuclease TnpB -
FF951_RS03155 (FF951_03210) 698678..699148 + 471 WP_003898523.1 hypothetical protein -
FF951_RS03160 (FF951_03215) 699193..699438 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FF951_RS03165 (FF951_03220) 699435..699836 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
FF951_RS03170 (FF951_03225) 699827..700006 + 180 Protein_628 hypothetical protein -
FF951_RS03175 (FF951_03240) 700424..700621 - 198 WP_003403191.1 hypothetical protein -
FF951_RS03180 (FF951_03245) 700701..701858 - 1158 WP_003898524.1 hypothetical protein -
FF951_RS03185 (FF951_03250) 701910..702131 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FF951_RS03190 (FF951_03255) 702273..702878 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T126506 WP_003403187.1 NZ_CP040688:699435-699836 [Mycobacterium tuberculosis complex sp. N0052]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T126506 NZ_CP040688:699435-699836 [Mycobacterium tuberculosis complex sp. N0052]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT126506 WP_003403184.1 NZ_CP040688:699193-699438 [Mycobacterium tuberculosis complex sp. N0052]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT126506 NZ_CP040688:699193-699438 [Mycobacterium tuberculosis complex sp. N0052]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References