Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 359818..360461 Replicon chromosome
Accession NZ_CP040688
Organism Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag FF951_RS01565 Protein ID WP_003401566.1
Coordinates 360036..360461 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag FF951_RS01560 Protein ID WP_003401563.1
Coordinates 359818..360039 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF951_RS01535 (FF951_01565) 354937..355740 - 804 WP_003401540.1 Stf0 family sulphotransferase -
FF951_RS01540 (FF951_01570) 355750..357147 - 1398 WP_003401544.1 sulfatase -
FF951_RS01545 (FF951_01575) 357326..359101 + 1776 WP_010886074.1 PE family protein -
FF951_RS01550 (FF951_01580) 359244..359471 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
FF951_RS01555 (FF951_01585) 359468..359770 + 303 WP_003401560.1 toxin-antitoxin system toxin -
FF951_RS01560 (FF951_01590) 359818..360039 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
FF951_RS01565 (FF951_01595) 360036..360461 + 426 WP_003401566.1 PIN domain nuclease Toxin
FF951_RS01570 (FF951_01600) 360597..361229 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
FF951_RS01575 (FF951_01605) 361226..362134 + 909 WP_003900117.1 protochlorophyllide reductase -
FF951_RS01580 362142..362732 - 591 WP_229298012.1 hypothetical protein -
FF951_RS01585 362725..362775 - 51 Protein_313 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T126500 WP_003401566.1 NZ_CP040688:360036-360461 [Mycobacterium tuberculosis complex sp. N0052]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T126500 NZ_CP040688:360036-360461 [Mycobacterium tuberculosis complex sp. N0052]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT126500 WP_003401563.1 NZ_CP040688:359818-360039 [Mycobacterium tuberculosis complex sp. N0052]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT126500 NZ_CP040688:359818-360039 [Mycobacterium tuberculosis complex sp. N0052]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References