Detailed information of TA system TA126498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 359244..359770
• Replicon: chromosome
• Accession: NZ_CP040688
• Organism: Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: FF951_RS01555
• Protein ID: WP_003401560.1
• Coordinates: 359468..359770 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: FF951_RS01550
• Protein ID: WP_003401555.1
• Coordinates: 359244..359471 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF951_RS01535 (FF951_01565)	354937..355740	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
FF951_RS01540 (FF951_01570)	355750..357147	-	1398	WP_003401544.1	sulfatase	-
FF951_RS01545 (FF951_01575)	357326..359101	+	1776	WP_010886074.1	PE family protein	-
FF951_RS01550 (FF951_01580)	359244..359471	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
FF951_RS01555 (FF951_01585)	359468..359770	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
FF951_RS01560 (FF951_01590)	359818..360039	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
FF951_RS01565 (FF951_01595)	360036..360461	+	426	WP_003401566.1	PIN domain nuclease	-
FF951_RS01570 (FF951_01600)	360597..361229	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
FF951_RS01575 (FF951_01605)	361226..362134	+	909	WP_003900117.1	protochlorophyllide reductase	-
FF951_RS01580	362142..362732	-	591	WP_229298012.1	hypothetical protein	-
FF951_RS01585	362725..362775	-	51	Protein_313	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T126498 WP_003401560.1 NZ_CP040688:359468-359770 [Mycobacterium tuberculosis complex sp. N0052]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T126498 NZ_CP040688:359468-359770 [Mycobacterium tuberculosis complex sp. N0052]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT126498 WP_003401555.1 NZ_CP040688:359244-359471 [Mycobacterium tuberculosis complex sp. N0052]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT126498 NZ_CP040688:359244-359471 [Mycobacterium tuberculosis complex sp. N0052]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1