Detailed information of TA system TA126497

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 73341..73974
• Replicon: chromosome
• Accession: NZ_CP040688
• Organism: Mycobacterium tuberculosis complex sp. N0052

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FF951_RS00365
• Protein ID: WP_003902592.1
• Coordinates: 73573..73974 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P0CW29
• Locus tag: FF951_RS00360
• Protein ID: WP_003400577.1
• Coordinates: 73341..73580 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF951_RS00345 (FF951_00355)	68637..70077	+	1441	Protein_65	FAD-binding oxidoreductase	-
FF951_RS00350 (FF951_00360)	70133..70294	+	162	WP_003899796.1	hypothetical protein	-
FF951_RS00355 (FF951_00365)	70335..73274	+	2940	WP_003901785.1	UPF0182 family protein	-
FF951_RS00360 (FF951_00370)	73341..73580	+	240	WP_003400577.1	antitoxin VapB1	Antitoxin
FF951_RS00365 (FF951_00375)	73573..73974	+	402	WP_003902592.1	type II toxin-antitoxin system ribonuclease VapC1	Toxin
FF951_RS00370 (FF951_00380)	74026..76263	-	2238	WP_003899797.1	NADP-dependent isocitrate dehydrogenase	-
FF951_RS00375 (FF951_00385)	76381..76950	-	570	WP_003400591.1	TetR/AcrR family transcriptional regulator	-
FF951_RS00380 (FF951_00390)	77053..77964	+	912	WP_003899798.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (24-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14349.48 Da
• Isoelectric Point: 4.8887

>T126497 WP_003902592.1 NZ_CP040688:73573-73974 [Mycobacterium tuberculosis complex sp. N0052]
VDECVVDAAAVVDALAGKGASAIVLRGLLKEPISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Nucleotide

• Length: 402 bp

>T126497 NZ_CP040688:73573-73974 [Mycobacterium tuberculosis complex sp. N0052]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGCCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8717.84 Da
• Isoelectric Point: 8.5960

>AT126497 WP_003400577.1 NZ_CP040688:73341-73580 [Mycobacterium tuberculosis complex sp. N0052]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Nucleotide

• Length: 240 bp

>AT126497 NZ_CP040688:73341-73580 [Mycobacterium tuberculosis complex sp. N0052]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Structures

Antitoxin

• AlphaFold DB: A0A829CHM7