Detailed information of TA system TA126491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 4559957..4560462
• Replicon: chromosome
• Accession: NZ_CP040684
• Organism: Pseudomonas aeruginosa strain C79

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: FF962_RS21950
• Protein ID: WP_003083773.1
• Coordinates: 4560181..4560462 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: FF962_RS21945
• Protein ID: WP_003083775.1
• Coordinates: 4559957..4560184 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF962_RS21920	4554974..4556467	+	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
FF962_RS21925	4556636..4558063	+	1428	WP_003083784.1	GABA permease	-
FF962_RS21930	4558146..4558487	-	342	WP_003101229.1	alkylphosphonate utilization protein	-
FF962_RS21935	4558560..4559060	-	501	WP_003162763.1	LEA type 2 family protein	-
FF962_RS21940	4559161..4559781	+	621	WP_003101226.1	hypothetical protein	-
FF962_RS21945	4559957..4560184	+	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
FF962_RS21950	4560181..4560462	+	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
FF962_RS21955	4560762..4561670	+	909	WP_003083769.1	LysR family transcriptional regulator	-
FF962_RS21960	4561702..4562088	-	387	WP_003083767.1	aegerolysin family protein	-
FF962_RS21965	4562292..4563026	-	735	WP_003110658.1	GntR family transcriptional regulator	-
FF962_RS21970	4563127..4563813	-	687	WP_003083762.1	FadR family transcriptional regulator	-
FF962_RS21975	4563862..4565211	-	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T126491 WP_003083773.1 NZ_CP040684:4560181-4560462 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T126491 NZ_CP040684:4560181-4560462 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGTAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT126491 WP_003083775.1 NZ_CP040684:4559957-4560184 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT126491 NZ_CP040684:4559957-4560184 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9