Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4839171..4839785 Replicon chromosome
Accession NZ_CP040677
Organism Kosakonia sacchari strain DSM 107661

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FGE25_RS23025 Protein ID WP_160271420.1
Coordinates 4839594..4839785 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FGE25_RS23020 Protein ID WP_045512440.1
Coordinates 4839171..4839581 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGE25_RS22980 4834274..4835158 - 885 WP_020455946.1 CDF family cation-efflux transporter FieF -
FGE25_RS22985 4835406..4836026 - 621 WP_160271415.1 type VI secretion protein -
FGE25_RS22990 4836037..4836369 - 333 WP_160271416.1 zinc ribbon domain-containing protein -
FGE25_RS22995 4836468..4836707 - 240 WP_160271417.1 ogr/Delta-like zinc finger family protein -
FGE25_RS23000 4837002..4837187 - 186 WP_020455942.1 hypothetical protein -
FGE25_RS23005 4837197..4837730 - 534 WP_160271418.1 DUF2514 family protein -
FGE25_RS23010 4837730..4838122 - 393 WP_160271419.1 M15 family metallopeptidase -
FGE25_RS23015 4838112..4838435 - 324 WP_020455939.1 phage holin family protein -
FGE25_RS23020 4839171..4839581 - 411 WP_045512440.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGE25_RS23025 4839594..4839785 - 192 WP_160271420.1 type II toxin-antitoxin system HicA family toxin Toxin
FGE25_RS23030 4839856..4840140 - 285 WP_160271421.1 ASCH domain-containing protein -
FGE25_RS23035 4840154..4840321 - 168 WP_160271422.1 hypothetical protein -
FGE25_RS23040 4840335..4840538 - 204 WP_160271423.1 hypothetical protein -
FGE25_RS23045 4840535..4842913 - 2379 WP_160271424.1 replication endonuclease -
FGE25_RS23050 4842916..4843158 - 243 WP_160271425.1 hypothetical protein -
FGE25_RS23055 4843373..4843591 - 219 WP_160271554.1 TraR/DksA C4-type zinc finger protein -
FGE25_RS23060 4843680..4843913 - 234 WP_160271426.1 DUF2732 family protein -
FGE25_RS23065 4843918..4844136 - 219 WP_160271427.1 hypothetical protein -
FGE25_RS23070 4844225..4844452 - 228 WP_160271428.1 DUF2724 domain-containing protein -
FGE25_RS23075 4844442..4844645 - 204 WP_160271555.1 DUF4761 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4836468..4846674 10206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 6905.13 Da        Isoelectric Point: 11.0942

>T126486 WP_160271420.1 NZ_CP040677:c4839785-4839594 [Kosakonia sacchari]
MNSRKLIAEIQADGWVLVRVTGSHYHFVHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGIQPAA

Download         Length: 192 bp

>T126486 NZ_CP040677:c4839785-4839594 [Kosakonia sacchari]
ATGAACAGCAGGAAGCTGATAGCAGAAATTCAGGCGGATGGGTGGGTGCTGGTAAGAGTAACAGGCAGTCATTACCACTT
CGTCCATCCAACAAAACCGGGGCTTGTGACGATACCCCACCCGAAAAAAGATTTACCGATTGGCACGGTAAAAAGCATAC
GAAAACAGGCGGGCATCCAGCCCGCCGCATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14828.90 Da        Isoelectric Point: 4.9344

>AT126486 WP_045512440.1 NZ_CP040677:c4839581-4839171 [Kosakonia sacchari]
MYYPIAIEAGDESHAYGVTVPDLPGCFSAGDTLDEAIKNAKEAIIGHIETLVELGRDVPPVSTAEKWSKNPAFAGYTWAL
VDIDVTRLLGGSEKINVTLPRFLIDRIDRCVATHPEYKTRSGFLAQAALERIAGIR

Download         Length: 411 bp

>AT126486 NZ_CP040677:c4839581-4839171 [Kosakonia sacchari]
ATGTATTATCCAATCGCAATCGAGGCCGGCGACGAAAGTCACGCTTACGGTGTGACAGTGCCGGATCTGCCTGGCTGCTT
TAGCGCGGGCGATACGCTTGATGAGGCGATCAAGAACGCGAAAGAGGCAATCATCGGACATATAGAAACGCTGGTCGAGC
TGGGCCGCGATGTTCCACCGGTTTCCACCGCGGAAAAGTGGTCAAAAAATCCAGCGTTTGCCGGGTATACGTGGGCGCTT
GTCGATATTGATGTGACTCGCCTGCTGGGCGGTTCCGAAAAAATCAACGTGACGCTGCCGCGCTTTCTGATCGACAGAAT
TGATCGGTGCGTTGCGACACATCCGGAGTACAAAACCCGCAGCGGGTTTCTGGCGCAGGCGGCTTTAGAGAGAATCGCAG
GCATCAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References