Detailed information of TA system TA126483

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3234181..3235085
• Replicon: chromosome
• Accession: NZ_CP040677
• Organism: Kosakonia sacchari strain DSM 107661

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FGE25_RS15400
• Protein ID: WP_020457219.1
• Coordinates: 3234621..3235085 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A4R0H5J7
• Locus tag: FGE25_RS15395
• Protein ID: WP_020457220.1
• Coordinates: 3234181..3234624 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGE25_RS15375	3229217..3230983	+	1767	WP_160270840.1	cysteine/glutathione ABC transporter permease/ATP-binding protein CydD	-
FGE25_RS15380	3230984..3232705	+	1722	WP_160270841.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-
FGE25_RS15385	3232812..3233513	+	702	WP_020457221.1	leucyl/phenylalanyl-tRNA--protein transferase	-
FGE25_RS15390	3233803..3234021	+	219	WP_001040187.1	translation initiation factor IF-1	-
FGE25_RS15395	3234181..3234624	+	444	WP_020457220.1	DUF2384 domain-containing protein	Antitoxin
FGE25_RS15400	3234621..3235085	+	465	WP_020457219.1	RES domain-containing protein	Toxin
FGE25_RS15405	3235188..3236576	+	1389	WP_045507234.1	diguanylate cyclase	-
FGE25_RS15410	3236644..3238935	-	2292	WP_017456165.1	ATP-dependent Clp protease ATP-binding subunit ClpA	-
FGE25_RS15415	3238966..3239286	-	321	WP_017456164.1	ATP-dependent Clp protease adapter ClpS	-
FGE25_RS15420	3239615..3239836	+	222	WP_007374119.1	cold shock-like protein CspD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-146)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (29-90)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17212.76 Da
• Isoelectric Point: 6.4855

>T126483 WP_020457219.1 NZ_CP040677:3234621-3235085 [Kosakonia sacchari]
VIFYRLVTRRYASEAWTGSGANLYGGRWNHKGHPAVYVASSVSLAALEMLVHMHSDAVMNQYGLFSIEIPDKEIEYLDKQ
WLPPDWQENPAPLSTMDLGTAWLEANSAVALVLPSCVVPLENNAILNPNHPAFNKLLKTVKALPFFFDPRLAHP

Nucleotide

• Length: 465 bp

>T126483 NZ_CP040677:3234621-3235085 [Kosakonia sacchari]
GTGATCTTTTATCGACTGGTAACGCGCCGCTACGCCAGCGAAGCCTGGACAGGCAGCGGTGCAAATCTTTATGGCGGTCG
CTGGAATCACAAAGGTCACCCGGCGGTTTACGTCGCCTCATCCGTTTCGCTTGCCGCACTCGAAATGCTGGTGCATATGC
ACAGTGACGCGGTTATGAACCAGTATGGACTGTTCAGTATTGAGATCCCTGACAAGGAGATTGAATATCTGGATAAGCAA
TGGCTACCGCCGGACTGGCAGGAAAACCCGGCGCCGCTTTCGACTATGGATTTAGGTACCGCCTGGCTGGAAGCCAACAG
CGCCGTCGCGCTGGTGCTGCCGTCATGCGTTGTTCCGCTTGAGAATAATGCAATTCTGAACCCGAATCACCCCGCTTTTA
ATAAGCTGTTAAAAACAGTAAAAGCGCTTCCTTTCTTTTTTGATCCACGCCTGGCACACCCGTAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16421.84 Da
• Isoelectric Point: 8.8231

>AT126483 WP_020457220.1 NZ_CP040677:3234181-3234624 [Kosakonia sacchari]
MRTWSPDQKPAENALWRFAGFPANRGLKLVQMLNEGLPVSILDNIHEWTEMSRSDILRVTGINERNVARRKSAGRTLTPE
ESERIARLVRVVDAAVQFFGSKKMAWDWLETPVRGLGNVAPISLIATESGALEVTDLLGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT126483 NZ_CP040677:3234181-3234624 [Kosakonia sacchari]
ATGAGAACCTGGAGCCCGGATCAAAAACCAGCCGAAAATGCACTCTGGCGCTTTGCCGGTTTCCCCGCCAACAGGGGGCT
AAAACTCGTTCAGATGTTGAACGAAGGCTTGCCAGTCAGCATTCTCGACAATATTCATGAATGGACAGAAATGTCCCGCT
CCGACATCCTGCGCGTCACGGGTATCAATGAACGGAATGTTGCGCGTCGCAAAAGCGCCGGCCGTACACTCACACCGGAA
GAAAGTGAGCGTATTGCGCGTTTAGTAAGGGTTGTTGATGCTGCGGTACAGTTTTTCGGTAGCAAAAAGATGGCGTGGGA
CTGGCTGGAAACCCCCGTTCGCGGCCTTGGCAATGTGGCGCCGATTTCGCTGATTGCCACTGAAAGTGGCGCGCTGGAAG
TGACCGACCTGCTCGGCAGGCTGGAACACGGAGTGTTTGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A4R0H5J7