Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 847767..848327 Replicon chromosome
Accession NZ_CP040677
Organism Kosakonia sacchari strain DSM 107661

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag FGE25_RS04110 Protein ID WP_160268776.1
Coordinates 847767..848078 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag FGE25_RS04115 Protein ID WP_020455098.1
Coordinates 848082..848327 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGE25_RS04090 843499..844074 + 576 WP_160268772.1 ABATE domain-containing protein -
FGE25_RS04095 844421..845488 - 1068 WP_160268774.1 SDR family oxidoreductase -
FGE25_RS04100 845592..846524 + 933 WP_020455101.1 LysR family transcriptional regulator -
FGE25_RS04105 846589..847710 + 1122 WP_045512544.1 cupin domain-containing protein -
FGE25_RS04110 847767..848078 - 312 WP_160268776.1 CcdB family protein Toxin
FGE25_RS04115 848082..848327 - 246 WP_020455098.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
FGE25_RS04120 848465..849181 - 717 WP_020455097.1 nitroreductase family protein -
FGE25_RS04125 849665..850096 + 432 WP_160268778.1 hypothetical protein -
FGE25_RS04130 850099..851013 - 915 WP_160268780.1 DNA-binding transcriptional regulator OxyR -
FGE25_RS04135 851224..852234 - 1011 WP_097406150.1 endoglucanase -
FGE25_RS04140 852278..853207 - 930 WP_020455092.1 UTP--glucose-1-phosphate uridylyltransferase GalU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-102)

Antitoxin

Post-segregation antitoxin CcdA

(11-81)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11765.54 Da        Isoelectric Point: 5.0896

>T126472 WP_160268776.1 NZ_CP040677:c848078-847767 [Kosakonia sacchari]
MQYSVYRNKSNSRDFPFLLDVQSDIIGSMNSRVVIPLCPLADYKDRRRVERLNPVLEIEGNSYLLLTHDLAGVSLAILGE
EVCSMRAQRDVIRNAMDFIFDGI

Download         Length: 312 bp

>T126472 NZ_CP040677:c848078-847767 [Kosakonia sacchari]
ATGCAATATTCGGTTTATCGGAACAAAAGTAACAGCCGGGATTTCCCGTTTCTGCTGGATGTACAGAGCGATATTATCGG
TAGCATGAACTCGCGGGTGGTGATCCCGCTCTGCCCACTGGCGGATTACAAAGATCGCCGCCGGGTTGAGCGGTTAAACC
CGGTACTGGAGATCGAAGGGAACTCGTATTTGTTACTGACCCACGATCTTGCAGGCGTCAGCCTGGCGATTTTGGGTGAA
GAGGTTTGCAGTATGCGCGCGCAGCGCGACGTGATCCGCAACGCGATGGATTTTATTTTTGACGGGATTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9214.35 Da        Isoelectric Point: 8.8279

>AT126472 WP_020455098.1 NZ_CP040677:c848327-848082 [Kosakonia sacchari]
MPATAPKQRNKQNVSVTVERELLEQARKEGINLSQTLATALQGELRNLAAERWKRENAAAIADLNEFIAERGHFSDEHRK
F

Download         Length: 246 bp

>AT126472 NZ_CP040677:c848327-848082 [Kosakonia sacchari]
ATGCCTGCTACTGCACCTAAACAGCGAAACAAGCAAAATGTCAGCGTGACCGTCGAGCGCGAGCTACTGGAACAAGCGCG
CAAAGAAGGCATCAACCTTTCGCAAACACTTGCGACCGCCTTGCAAGGTGAACTGCGCAATCTGGCAGCTGAGCGCTGGA
AGCGCGAAAATGCCGCCGCCATTGCCGATCTAAATGAATTTATTGCCGAACGCGGCCACTTCTCGGATGAACACAGGAAG
TTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References