Detailed information of TA system TA126468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 52555..53080
• Replicon: plasmid SA20082869 strain 14[5]12:i:-
• Accession: NZ_CP040669
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain SA20082869

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: FGO77_RS24555
• Protein ID: WP_001159863.1
• Coordinates: 52555..52860 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: FGO77_RS24560
• Protein ID: WP_000813641.1
• Coordinates: 52862..53080 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGO77_RS24515	47935..48495	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
FGO77_RS25110	48651..48938	+	288	WP_071530243.1	hypothetical protein	-
FGO77_RS24520	49215..49700	-	486	WP_000905606.1	membrane protein	-
FGO77_RS24525	49694..50203	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
FGO77_RS24535	50207..50919	-	713	Protein_52	EAL domain-containing protein	-
FGO77_RS24540	50928..51710	-	783	WP_000082169.1	site-specific integrase	-
FGO77_RS24545	51745..52266	-	522	WP_000198608.1	hypothetical protein	-
FGO77_RS24550	52263..52553	-	291	WP_001266176.1	hypothetical protein	-
FGO77_RS24555	52555..52860	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
FGO77_RS24560	52862..53080	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
FGO77_RS24565	53756..54277	+	522	WP_010999942.1	hypothetical protein	-
FGO77_RS24575	54761..55057	+	297	WP_001687482.1	hypothetical protein	-
FGO77_RS24580	55551..56540	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
FGO77_RS24590	56899..57603	+	705	WP_001067858.1	IS6-like element IS26 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..107560	107560

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-70)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T126468 WP_001159863.1 NZ_CP040669:c52860-52555 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T126468 NZ_CP040669:c52860-52555 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT126468 WP_000813641.1 NZ_CP040669:c53080-52862 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT126468 NZ_CP040669:c53080-52862 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6