Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 860815..861292 Replicon chromosome
Accession NZ_CP040665
Organism Staphylococcus aureus strain D592

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FFX42_RS04140 Protein ID WP_000052076.1
Coordinates 860815..861003 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FFX42_RS04145 Protein ID WP_001059690.1
Coordinates 861032..861292 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFX42_RS04110 856809..857330 + 522 WP_000824482.1 hypothetical protein -
FFX42_RS04115 857671..858357 + 687 WP_000141557.1 thermonuclease family protein -
FFX42_RS04120 858714..858914 + 201 WP_001059082.1 cold-shock protein -
FFX42_RS04125 859406..859624 - 219 WP_000005886.1 hypothetical protein -
FFX42_RS04130 859701..859970 - 270 WP_001004398.1 hypothetical protein -
FFX42_RS04135 860058..860627 - 570 WP_001106658.1 hypothetical protein -
FFX42_RS04140 860815..861003 - 189 WP_000052076.1 hypothetical protein Toxin
FFX42_RS04145 861032..861292 - 261 WP_001059690.1 hypothetical protein Antitoxin
FFX42_RS04150 861633..861836 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FFX42_RS04155 861833..862069 - 237 WP_000349581.1 hypothetical protein -
FFX42_RS04160 862294..862875 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FFX42_RS04165 862948..863565 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
FFX42_RS04170 863720..864214 - 495 WP_000569883.1 GNAT family N-acetyltransferase -
FFX42_RS04180 864613..865035 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FFX42_RS04185 865183..865899 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T126422 WP_000052076.1 NZ_CP040665:c861003-860815 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T126422 NZ_CP040665:c861003-860815 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT126422 WP_001059690.1 NZ_CP040665:c861292-861032 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT126422 NZ_CP040665:c861292-861032 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References