Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 56825..57350 Replicon plasmid SA20070548 strain 14[5]12:i:-
Accession NZ_CP040652
Organism Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain SA20070548

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag FGF59_RS24680 Protein ID WP_001159871.1
Coordinates 56825..57130 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag FGF59_RS24685 Protein ID WP_000813634.1
Coordinates 57132..57350 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGF59_RS24650 52414..53004 + 591 Protein_64 colicin-B -
FGF59_RS24655 53020..53717 - 698 Protein_65 IS1 family transposase -
FGF59_RS24660 54117..54814 - 698 Protein_66 IS1 family transposase -
FGF59_RS24665 54871..55440 + 570 Protein_67 lipid II-degrading bacteriocin colicin M -
FGF59_RS24670 55490..55843 - 354 WP_000864813.1 colicin M immunity protein -
FGF59_RS24965 55790..55914 - 125 Protein_69 colicin immunity protein -
FGF59_RS24675 56015..56824 - 810 WP_000016963.1 site-specific integrase -
FGF59_RS24680 56825..57130 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
FGF59_RS24685 57132..57350 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
FGF59_RS24695 57909..58835 + 927 WP_001290414.1 hypothetical protein -
FGF59_RS24700 58885..59139 + 255 WP_000678528.1 hypothetical protein -
FGF59_RS24705 59637..59981 + 345 WP_000792769.1 hypothetical protein -
FGF59_RS24710 60155..61156 - 1002 WP_000785695.1 DUF4238 domain-containing protein -
FGF59_RS24720 61729..62019 - 291 WP_000648897.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..84296 84296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T126294 WP_001159871.1 NZ_CP040652:c57130-56825 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T126294 NZ_CP040652:c57130-56825 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT126294 WP_000813634.1 NZ_CP040652:c57350-57132 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT126294 NZ_CP040652:c57350-57132 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References