Detailed information of TA system TA126293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 25997..26522
• Replicon: plasmid pCFSAN074385
• Accession: NZ_CP040647
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain SAP18-H9654

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: FF982_RS23035
• Protein ID: WP_001159863.1
• Coordinates: 25997..26302 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: FF982_RS23040
• Protein ID: WP_000813641.1
• Coordinates: 26304..26522 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF982_RS23000	21376..21936	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
FF982_RS23005	22656..23141	-	486	WP_000905606.1	membrane protein	-
FF982_RS23010	23135..23644	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
FF982_RS23015	23648..24361	-	714	WP_000545756.1	EAL domain-containing protein	-
FF982_RS23020	24370..25152	-	783	WP_000082169.1	site-specific integrase	-
FF982_RS23025	25187..25708	-	522	WP_000198608.1	hypothetical protein	-
FF982_RS23030	25705..25995	-	291	WP_001266176.1	hypothetical protein	-
FF982_RS23035	25997..26302	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
FF982_RS23040	26304..26522	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
FF982_RS23045	27198..27719	+	522	WP_077681952.1	hypothetical protein	-
FF982_RS23405	27763..28191	-	429	Protein_33	hypothetical protein	-
FF982_RS23055	28203..28498	+	296	Protein_34	cytoplasmic protein	-
FF982_RS23060	28992..29981	+	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
FF982_RS23065	30308..30469	-	162	WP_015059604.1	hypothetical protein	-
FF982_RS23070	30522..30908	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59372	59372

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T126293 WP_001159863.1 NZ_CP040647:c26302-25997 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T126293 NZ_CP040647:c26302-25997 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT126293 WP_000813641.1 NZ_CP040647:c26522-26304 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT126293 NZ_CP040647:c26522-26304 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6