Detailed information of TA system TA126292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 51746..52271
• Replicon: plasmid pCFSAN074386
• Accession: NZ_CP040645
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain SAP18-0432

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: FF980_RS23245
• Protein ID: WP_001159863.1
• Coordinates: 51966..52271 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: FF980_RS23240
• Protein ID: WP_000813641.1
• Coordinates: 51746..51964 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF980_RS23210	47360..47746	+	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-
FF980_RS23215	47799..47960	+	162	WP_015059604.1	hypothetical protein	-
FF980_RS23220	48287..49276	-	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
FF980_RS23225	49770..50065	-	296	Protein_64	cytoplasmic protein	-
FF980_RS23440	50077..50505	+	429	Protein_65	hypothetical protein	-
FF980_RS23235	50549..51070	-	522	WP_077681952.1	hypothetical protein	-
FF980_RS23240	51746..51964	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
FF980_RS23245	51966..52271	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
FF980_RS23250	52273..52563	+	291	WP_001266176.1	hypothetical protein	-
FF980_RS23255	52560..53081	+	522	WP_000198608.1	hypothetical protein	-
FF980_RS23260	53116..53898	+	783	WP_000082169.1	site-specific integrase	-
FF980_RS23265	53907..54620	+	714	WP_000545756.1	EAL domain-containing protein	-
FF980_RS23270	54624..55133	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
FF980_RS23275	55127..55612	+	486	WP_000905606.1	membrane protein	-
FF980_RS23280	55889..56176	-	288	WP_071530243.1	hypothetical protein	-
FF980_RS23285	56332..56892	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59372	59372

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• SpoVT-AbrB domain (7-55)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T126292 WP_001159863.1 NZ_CP040645:51966-52271 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T126292 NZ_CP040645:51966-52271 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT126292 WP_000813641.1 NZ_CP040645:51746-51964 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT126292 NZ_CP040645:51746-51964 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6