Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 946142..947665 Replicon chromosome
Accession NZ_CP040641
Organism Agrobacterium sp. T29

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag FGF54_RS19405 Protein ID WP_142780809.1
Coordinates 946421..947665 (+) Length 415 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag FGF54_RS19400 Protein ID WP_142780808.1
Coordinates 946142..946408 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGF54_RS19380 941901..942842 + 942 WP_142780804.1 sugar phosphate isomerase/epimerase -
FGF54_RS19385 942898..943827 + 930 WP_142780805.1 sugar phosphate isomerase/epimerase -
FGF54_RS19390 944006..945109 + 1104 WP_142780806.1 agmatine deiminase family protein -
FGF54_RS19395 945392..945769 - 378 WP_142780807.1 HNH endonuclease -
FGF54_RS19400 946142..946408 + 267 WP_142780808.1 helix-turn-helix transcriptional regulator Antitoxin
FGF54_RS19405 946421..947665 + 1245 WP_142780809.1 type II toxin-antitoxin system HipA family toxin Toxin
FGF54_RS19410 947912..948994 + 1083 WP_142780810.1 hypothetical protein -
FGF54_RS19415 949524..950420 + 897 WP_142780811.1 hypothetical protein -
FGF54_RS19420 950497..950886 + 390 WP_142780812.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 946142..965423 19281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(137-370)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 415 a.a.        Molecular weight: 45860.49 Da        Isoelectric Point: 6.8295

>T126241 WP_142780809.1 NZ_CP040641:946421-947665 [Agrobacterium sp. T29]
MTTIYYENWSVAHLSDQDGLALSYDAEWEKRSSAFPLSLTTPMRAGSYGAERVMPWLANLLPETHLSEIGQQLKVSPQDV
IGLLLRVGRDTAGAFSIGEPRREGNNFRIVDDGEALERIIDELPERPFLIGERGVSMSLAGVQDKLPVYIDYEGRIGIPV
DGTPSTHILKPDIKRLAGSVTNEAFCMILARLCGLDVAEVTMGRAGTRDYLLVRRYDRVADRQGVIRRIHQEDFCQLLGL
FPAEKYEQTGLGQRGGASLPQMFQALARLVSPAERIRLLDAVIFNILICNSDSHAKNYSVLVGASGTARLAPLYDLMCAS
PYKQVDQSLPQQLAGKRNADELHAKDWRQFAADVGLSPAAVTRRVVELAALVATKADEALDHVQSYPVSNRELASSLVFL
IRKRCRRIERQISA

Download         Length: 1245 bp

>T126241 NZ_CP040641:946421-947665 [Agrobacterium sp. T29]
TTGACGACTATCTACTACGAGAACTGGTCTGTTGCGCACTTGTCGGATCAGGATGGCCTAGCTCTCTCATACGACGCAGA
GTGGGAGAAACGGTCCTCAGCCTTCCCATTGTCGCTTACGACGCCAATGCGCGCAGGCAGCTATGGGGCCGAACGGGTCA
TGCCGTGGCTCGCGAACCTGCTGCCGGAAACCCATCTGTCCGAAATTGGCCAGCAGCTCAAGGTGTCGCCCCAGGACGTA
ATCGGTCTCCTGCTGCGTGTCGGCCGCGATACGGCAGGTGCCTTCTCGATCGGTGAGCCGCGACGGGAGGGAAATAATTT
CCGCATCGTCGATGACGGGGAAGCACTTGAGCGCATCATCGACGAACTGCCGGAGCGGCCATTCCTGATCGGTGAGCGGG
GCGTCTCAATGTCGCTTGCAGGCGTCCAGGACAAGCTCCCCGTCTACATCGATTACGAAGGTCGGATCGGCATACCGGTT
GACGGCACCCCTTCGACCCACATCCTGAAGCCCGACATCAAACGTCTTGCGGGGAGCGTCACCAATGAAGCGTTCTGCAT
GATCCTCGCAAGGCTCTGCGGGCTGGACGTTGCCGAAGTGACAATGGGCCGTGCAGGAACACGGGACTATCTTCTCGTCC
GCCGCTATGACCGGGTTGCTGACCGCCAAGGTGTCATCCGCCGCATACACCAAGAAGACTTCTGCCAGCTGCTGGGACTG
TTCCCGGCGGAGAAGTATGAGCAAACCGGTCTCGGTCAGCGTGGCGGCGCATCACTGCCGCAGATGTTTCAAGCCTTGGC
GCGCCTTGTCTCGCCCGCCGAACGCATCCGTCTGCTTGACGCGGTGATCTTCAACATCCTGATCTGTAACTCGGACTCGC
ATGCGAAAAACTACTCGGTGCTTGTCGGCGCGTCCGGCACCGCGAGACTCGCGCCGCTCTACGATCTGATGTGCGCGTCA
CCCTACAAGCAGGTCGATCAATCTCTGCCCCAGCAACTGGCCGGCAAGCGCAACGCCGACGAGTTGCACGCGAAGGACTG
GCGTCAGTTTGCCGCCGATGTCGGGCTTAGTCCCGCTGCCGTAACCAGGCGCGTCGTGGAGCTCGCCGCTCTGGTCGCGA
CCAAGGCAGACGAGGCACTTGACCACGTCCAATCGTACCCGGTTTCAAATCGCGAACTTGCGTCCAGCCTCGTCTTTCTC
ATCAGGAAGAGATGTAGGCGGATCGAGCGGCAGATTTCGGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9698.03 Da        Isoelectric Point: 5.0648

>AT126241 WP_142780808.1 NZ_CP040641:946142-946408 [Agrobacterium sp. T29]
MIRSAAEFGALVREYRKKQGWTQTQLAERCGTGERFIVDLENGKPSCQLEKSLIAARTVGLNLGDLNAISSLPIPAADDD
LDYLPRFS

Download         Length: 267 bp

>AT126241 NZ_CP040641:946142-946408 [Agrobacterium sp. T29]
ATGATCCGTTCAGCGGCAGAATTCGGCGCGCTTGTTCGAGAATACCGAAAGAAGCAGGGATGGACGCAAACCCAGCTCGC
TGAGCGCTGTGGCACCGGGGAACGCTTCATCGTCGATCTAGAAAACGGCAAGCCAAGCTGTCAGCTTGAGAAATCCCTGA
TCGCGGCCAGAACGGTTGGACTTAACCTCGGCGACCTGAATGCGATCTCGTCCTTGCCGATTCCGGCAGCCGATGACGAC
CTCGACTACCTGCCGCGCTTTTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References